Volume : 11, Issue : 10, October – 2024
Title:
DESIGN AND DEVELOPMENT OF BUCCAL MUCOADHESIVE TABLETS OF LOSARTAN POTASSIUM BY AGELE MARMELOS GUM
Authors :
O.Girija Kumari *, Ch.Pooja , SK.Imran, T.Bharath, T.Sruthi and V.RishiJN Suresh Kumar
Abstract :
In the present work, the mucoadhesive tablet of Losartan Potassium(as a model drug) by using Aegle marmelos fruit gum as a binder was formulated. The preliminary evaluation of Aegle marmelos gum showed that bulk density 0.45 ± 0.2 g/cm3, tapped density 0.50 ± 0.3 g/cm3 and angle of repose 300 ± 0.2. The four tablet formulation were prepared by using of Aegle marmelos gum and drug ratios 1:0.5, 1:0.75 1:1, 1:1.25 by direct compression technique (F1,F2,F3, andF4 respectively). Tablets were subjected for evaluation of uniformity of weight, hardness, friability, drug content uniformity, swelling behavior, release rate study, mucoadhesive study, and tensile strength study. Formulation was studied for drug additive interaction (FTIR). F4 was found to be optimized formulation. The in-vitro drug release of F4 formulation exhibits complete release of Losartan Potassiumwith zero order release kinetics and followed by Higuchi mechanism. From the study it can be conclude that the Aegle marmelos gum used as mucoadhesive sustained release matrix tablet.
Cite This Article:
Please cite this article in press O.Girija Kumari et al., Design And Development Of Buccal Mucoadhesive Tablets Of Losartan Potassium By Agele Marmelos Gum,Indo Am. J. P. Sci, 2024; 11 (10).
Number of Downloads : 10
References:
1. Ghanshyam M Chavan , Jyothirmayee D. Formulation Development of Mucoadhesive Tablets for Treatment of Hypertension using Losartan Potassium, International Journal of Drug Delivery Technology. 2023; 13(4):1483-1488.
2. Koirala S, Nepal P, Ghimire G, Basnet R, Rawat I, Dahal A, Pandey J, Parajuli-Baral K. Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac. Heliyon. 2021 Mar 1;7(3): e06439.
3. Mohanty C, Subrahmanyam K. Design of Controlled Release Mucoadhesive Buccal Tablets of Ivabradine Hcl Using Sintering Technique. International Journal of Applied Pharmaceutics. 2021 July; 13(4)192-203.
4. Kotadiya R, Shah K. Development of Bioadhesive Buccal Tablets of Nicorandil Using a Factorial Approach Turk J Pharm Sci 2020;17(4):388-397.
5. Esim O, Savaser A, Ozkan CK, Tas C, Ozkan Y. Investigation of the mucoadhesivity, swelling, and drug release mechanisms of indomethacin buccal tablets: effect of formulation variables. Drug Development and Industrial Pharmacy. 2020 Dec 1;46(12):1979-1987.
6. Grewal P, Mundlia J, Ahuja M. Thiol modified Moringa gum–A potential bioadhesive polymer. Carbohydrate polymers. 2019 Apr 1;209:400-408.
7. Li P, Zhang DK, Lin JZ, Han X, Ke XM, Han L, Yang M, Liu HN. Optimized model for formulation prescription of traditional Chinese medicine buccal tablets based on temporal dominant description of sensations combined with multivariate statistical analysis: an example of Compound Caoshanhu Buccal Tablets. China journal of Chinese materia medica. 2019 Jul 1;44(14):3035-41.
8. Martins ICF, Raposo NRB, Mockdeci HR, Polonini HC, de Oliveira Ferreira A, Fabri GMC, das Gracas Afonso Miranda Chaves M. Delivering Resveratrol on the Buccal Mucosa Using Mucoadhesive Tablets: A Potential Treatment Strategy for Inflammatory Oral Lesions. Curr Drug Deliv. 2018 Feb 14;15(2):254-259.
9. El-Nahas AE, Allam AN, El-Kamel AH. Mucoadhesive buccal tablets containing silymarin Eudragit-loaded nanoparticles: formulation, characterisation and ex vivo permeation. Journal of microencapsulation. 2017 Jul 4;34(5):463-474.
10. Panda B, Subhadarsini R, Mallick S. Biointerfacial phenomena of amlodipine buccomucosal tablets of HPMC matrix system containing polyacrylate polymer/β-cyclodextrin: correlation of swelling and drug delivery performance. Expert opinion on drug delivery. 2016 May 3;13(5):633-643.
11. Abruzzo A, Cerchiara T, Bigucci F, Gallucci MC, Luppi B. Mucoadhesive buccal tablets based on chitosan/gelatin microparticles for delivery of propranolol hydrochloride. Journal of pharmaceutical sciences. 2015 Dec 1;104(12):4365- 4372.