Volume : 11, Issue : 10, October – 2024
Title:
FORMULATION AND INVITRO CHARACTERIZATION OF IVACAFTOR SOLID DISPERSION TABLETS
Authors :
Pooja Macharla*, Aukunuru Jitha
Abstract :
Ivacaftor is a cystic fibrosis transmembrane conductance regulator to treat and prevent certain types of serious, life-threatening ventricular arrhythmias.It is an BCS class-II drug having higher half-life. To improve the biological performance of Ivacaftor solid dispersion with oral disintegrating tablet was formulated by using SSG, Soluplus and PVP K-30. Solid dispersions of Ivacaftor were prepared with different carriers in differentratios of drug and carrier(1:1, 1:2,1:3 &1:4). Results of prepared solid dispersions of Ivacaftor by solvent evaporation method were discussed which includes solubility, melting point determination, drug content uniformity, and invitro dissolution studies.Characterization in solid state was done by various analytical techniques such as FT-IRstudies .Finally by comparing all the formulations, formulation (F12) containing Ivacaftor + PVP K30 (1:4) shows better results by solvent evaporation method at the end of 60 min with maximum drug release, hence it was selected as the best formulation.From the optimized formulation the Fast dissolvingtablets were formulated using different disintegrants in different concentrations.The pre compression and post compression parameters were studied and the results were given. all the results are in the acceptable limit.The in vitro drug release of the formulated tablets were performed using 6.8 pH Phosphate buffer. F12T12 formulation containing Crospovione shows 98.21% drug release in 30mins. The optimized formulation follows First order release kinetics.
Keywords: Ivacaftor, Crospovidone, PVP K30 & FTIR.
Cite This Article:
Please cite this article in press Pooja Macharla et al Formulation And Invitro Characterization Of Ivacaftor Solid Dispersion Tablets ..,Indo Am. J. P. Sci, 2024; 11 (10).
Number of Downloads : 10
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