Volume : 11, Issue : 10, October – 2024
Title:
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF CLOBAZAM BY USING WET GRANULATION METHOD
Authors :
Aukunuru Jithan, Sravani Marripalli
Abstract :
An Orally disintegrating tablet disperses readily in saliva and the drug is available in solution or suspension form for the immediate absorption and resulting in rapid onset of action. In the present research work Clobazam Orally disintegrating tablet were prepared by intra and extra granulation technique method using varying concentrations of Fenugreek Gum, Karaya Gum and Crospovidoneas super disintegrants. The formulations prepared were evaluated for precompression & post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Clobazam) and optimized formulation (Clobazam + excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing concentration of Crospovidone shows 99.72% of the drug release within 60 min & follows first order kinetics. The overall result indicated that the formulation F12 containing Crospovidone is better and fulfilling of the needs of the Orally disintegrating tablet.
Crucial words: Orally disintegrating tablet, Clobazam, Crospovidone, FTIR.
Cite This Article:
Please cite this article in press Sravani Marripalli et al Formulation And Evaluation Of Immediate Release Tablets Of Clobazam By Using Wet Granulation Method..,Indo Am. J. P. Sci, 2024; 11 (10).
Number of Downloads : 10
References:
1. GS Banker; NR Anderson, Tablets in: The theory and practice of industrial pharmacy 3rdEd. Varghese publishing house, Mumbai, 1987, 314-324.
2. EL Parrot. Compression in pharmaceutical dosage form, tablets. Marcel Dekker Inc. New York, 1990; 2:153-182.
3. Lehman, HA Liberman, L.J. Kanig, theory and practice of industrial pharmacy 3rd Ed.vargese publication house, Mumbai,1990, 293-294; 329-335.
4. Ansel’s Pharmaceutical dosage form and Drug Delivery systems. Ninth Edition. Anisul Quardir, Karl Kolter 2006. A comparative study of current Super disintegrents, pharmaceutical technology.
5. Anisul Quardir, Karl Kolter 2006. A comparative study of current Super disintegrents, pharmaceutical technology.
6. Shyamala, B. & Narmada, G. Y. (2002) Rapid dissolving tablets: A novel dosage form, The Indian Pharmacist, 13: 9–12.
7. Lehmann cr, et.al. Metoclopramide kinetics in patients with impaired renal function and clearance by haemodialysis.clin Pharmacol ther 1985; 37;284-9.
8. Chien YW. Novel drug delivery systems. Marcel Dekker Inc. 2nd Ed. 1992:139-40.
9. Leah E, Appel DT, Friesen JE, Byers MD, Crew BC, Hancock SJ, Schadtle. Immediate release dosage forms containing solid drug dispersion. United States Patent No. 424465; 2002.
10. A Review On New Generation Orodispersible Tablets And Its Future Prospective, Tanmoy Ghosh, Amitava Ghosh And Devi Prasad, International Journal of Pharmacy and Pharmaceutical Sciences , 2011; 3(1):1491.
11. Jon Gabriel son, Nils-Olof Lindberg and Torbjorn Lundstedt , Multivariate Methods in Pharmaceutical Applications, J. Chemom 2002; 16:141-160.
12. Susijit Sahoo, B. Mishra, P.IK. Biswal, Omprakash Panda, Santosh Kumar Mahapatra, Goutam Kumar Jana, Fast Dissolving Tablet: As A Potential Drug Delivery System, Drug Invention Today 2010, (2), 130-133.
13. Margret Chandira. R., Jayakar.B, Pasupathi, A. Chakrabarty, B.L.Maruya P, Design, Development and evaluation of immediate release atorvastatin and sustained release gliclazide tablets. Journal of Pharmacy Research, 2009;2(6).
14. Vaishali Kilor, Nidhi Sapkal, Jasmine Awari, Bharti Shewale, Development and characterization of Enteric-Coated Immediate-Release Pellets of Aceclofenac by Extrusion/Spheronization Technique Using Carrageenan as a pelletizing Agent, AAPS PharmSciTech 2010; 11( 1):336-343.
15. B.G. Shiyani, R.B. Dholakiyal, B.V. Akbari, D.J. Lodhiyal, G.K. Ramani, Development and evaluation of novel immediate release tablets of Metoclopramide HCI by direct compression using treated gellan gum as disintegration-accelerating agent. Journal of Pharmacy Research 2009, 2(9), 1460-1464.