Volume : 11, Issue : 10, October – 2024
Title:
ADVANCES IN LIPOSPHERE TECHNOLOGY FOR THE DELIVERY OF BCS CLASS II DRUGS: A REVIEW
Authors :
Osama Uddin*, Dr. Satkar Prasad
Abstract :
Lipospheres have emerged as promising drug delivery systems for Biopharmaceutical Classification System (BCS) Class II drugs, characterized by low solubility and high permeability. This review explores the formulation strategies, physicochemical properties, and pharmacokinetic advantages of lipospheres in enhancing the bioavailability and therapeutic efficacy of BCS Class II compounds. The lipid-based nature of lipospheres allows for improved drug solubilization, stability, and controlled release profiles, addressing the challenges associated with these poorly water-soluble drugs. Additionally, the impact of lipid composition, particle size, and surface modifications on drug encapsulation efficiency and release kinetics are discussed. Furthermore, recent advancements in liposphere technology, including hybrid and targeted delivery systems, are highlighted to underscore their potential in optimizing the delivery of BCS Class II drugs. This comprehensive review provides insights into the current state of lipospheres as versatile carriers for enhancing the oral delivery of poorly soluble drugs, thereby fostering new opportunities in pharmaceutical development and therapeutic applications.
Keywords: Lipospheres, BCS Class II drugs, drug delivery systems, bioavailability, solubility enhancement, lipid-based carriers, controlled release, drug encapsulation, pharmacokinetics, poorly soluble drugs.
Cite This Article:
Please cite this article in press Osama Uddin et al., Advances In Liposphere Technology For The Delivery Of BCS CLASS II Drugs: A Review.,Indo Am. J. P. Sci, 2024; 11 (10).
Number of Downloads : 10
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