Volume : 11, Issue : 10, October – 2024

Title:

FORMULATION OF COLON TARGETING NANOSPONGES FOR EFFECTIVE TREATMENT OF AMOEBIASIS

Authors :

Anjali Verma, Dr. Rajeev Kumar Malviya

Abstract :

This study explores the formulation of diloxanide furoate-loaded nanosponges aimed at enhancing the drug’s bioavailability for the effective treatment of amoebiasis. Various formulations were developed using poly-methyl-methacrylate and Eudragit S-100, optimizing parameters such as yield, entrapment efficiency, and in vitro drug release. The results indicated that formulation F3 achieved the highest percentage yield (84.45%) and entrapment efficiency (82.23%). In vitro release studies demonstrated a significant improvement in drug release profiles, with 98.74% of diloxanide furoate released over 12 hours, indicating a sustained release mechanism. The study suggests that these nanosponges may offer a promising strategy for targeted drug delivery to the colon, potentially improving therapeutic outcomes in amoebiasis treatment.
Keywords: Diloxanide furoate, nanosponges, amoebiasis, targeted drug delivery, bioavailability, Eudragit S-100, sustained release.

Cite This Article:

Please cite this article in press Anjali Verma et al., Formulation Of Colon Targeting Nanosponges For Effective Treatment Of Amoebiasis.,Indo Am. J. P. Sci, 2024; 11 (10).

Number of Downloads : 10

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