Volume : 11, Issue : 09, September – 2024
Title:
FABRICATION AND OPTIMIZATION OF EMULSOMES CONTAINING TOPICAL GEL OF KETOCONAZOLE
Authors :
MD Reyaz, Roshani Nayak, Dharmendra Singh Rajput, Naveen Gupta
Abstract :
Abstract:
The topical route of administration for a therapeutic drug allows for direct contact with the intended area of the skin. Topical dosage forms such as ointments, creams, and gels are often inadequate in delivering medication to the desired spot, especially in higher concentrations. Advanced drug delivery systems such as liposomes, emulsomes, niosomes, dendrimers, and nanoparticles have the ability to specifically target tissues through the skin layer, offering improved therapeutic options for skin cancer. The findings indicate that when the concentration of the solid core changes and the quantity of lipid content increases, there is a corresponding rise in particle size. Consequently, this leads to an increase in both the PDI (polydispersity index) and the zetapotential action. The results of the dependent variables indicated that the KE4 formulation was chosen to optimize the impact of different surfactants at varying concentrations on the penetration rate or drug entrapment efficiency inside the solid lipid core. The gel basis is required to advance the formulation from emulsomes to emulsomal gel. The gel basis, consisting of a mix of guargum and xanthan gum, was chosen as the optimal concentration of gelling agent. The emulsomes were formulated and converted into an emulsomal gel, which was then assessed using several criteria. The physical assessment of the emulsomal gels revealed a bright yellow color, transparency, and a desirable consistency and smooth texture. The pH of the formulation does not disrupt the physiological balance of the skin. The analysis determined that the KEG4 formulation performed the best across all observations. The drug release perfusion profile and release kinetics of formulations KEG1 to KEG4 exhibited values of n> 0.5, indicating that they followed the Fickian diffusion and supercase II transport mechanism.
Cite This Article:
Please cite this article in press MD Reyaz et al., Fabrication And Optimization Of Emulsomes Containing Topical Gel Of Ketoconazole, Indo Am. J. P. Sci, 2024; 11 (09).
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References:
1. Gennari C.G.M., Selmin F., Minghetti P., Cilurzo F. Medicated foams and film forming dosage forms as tools to improve the thermodynamic activity of drugs to be administered through the skin. Curr. Drug Deliv. 2019;16:461–471.
2. Bolat Z.B., Islek Z., Demir B.N., Yilmaz E.N., Sahin F., Ucisik M.H. Curcumin- and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model. Front. Bioeng. Biotechnol. 2020;8:1–21.
3. Khan A.S., Shah K.U., Al Mohaini M., Alsalman A.J., Al Hawaj M.A., Alhashem Y.N., Ghazanfar S., Khan K.A., Niazi Z.R., Farid A. Tacrolimus-loaded solid lipid nanoparticle gel: formulation development and in vitro assessment for topical applications. Gels. 2022;8:129.
4. Arien A, Dupuy B. Encapsulation of calcitonin in liposomes depends in the vesicle preparationmethod.JMicroencapsul, 1997; 14: 753-760.
5. Humberstone AJ, Charman WN. Lipid-based vehicles for the oral delivery of poorly water soluble drugs. Adv Drug Deliv Rev 1997; 25:103-28.
6. Vyas SP, Gupta S, Dube A. Antileishmanial efficacy of amphotericin b bearing emulsomes against experimental visceral leishmaniasis. J Drug Target 2007; 15:437-44.
7. Camilo C.J.J., Leite D.O.D., Silva A.R.A., Menezes I.R.A., Coutinho H.D.M., Costa J.G.M. Lipid vesicles: applications, principal components and methods used in their formulations: a review. Acta Biol. Colomb. 2020;25:339–352.
8. Brocks DR, Betageri GV. Enhanced oral absorption of halofantrine enantiomers after encapsulation in a proliposomal formulation. J Pharm Pharmacol 2002; 54:1049-53.
9. Chambin O, Jannin V. Interest of multifunctional lipid excipients: Case of Gelucire 44/14. Drug Dev Ind Pharm 2005; 31:527-34.
10. Schwarz C, Mehnert W, Lucks JS, Muller RH. Solid lipid nanoparticles (SLNs) for controlled drug delivery: I. Production, characterization and sterilization. J Control Release 1994;30:83-96.
11. Song F., Chen J., Zheng A., Tian S. Effect of sterols on liposomes: Membrane characteristics and physicochemical changes during storage. LWT. 2022;164
12. Fang JY, Hong CT, Chiu WT, Wang YY. Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm 2001; 219:61-72.
13. Lowell GH, Kaminski RW, VanCott TC, Slike B, Kersey K, Zawoznik E, et al. Proteosomes, emulsomes, and cholera Toxin B Improve nasal immunogenicity of human immunodeficiency virus Gp160 in mice: Induction of serum, intestinal, vaginal, and Lung IgA and IgG. J Infect Dis 1997; 175: 292-301.
14. Azeem A, Anwer MK, Talegaonkar S. Niosomes in sustained and targeted drug delivery: Some recent advances. J Drug Target 2009; 17:671-89.
15. Fang JY, Hong CT, Chiu WT, Wang YY. Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm 2001; 219:61-72.