Volume : 11, Issue : 09, September – 2024
Title:
PREPARATION AND OPTIMIZATION OF DEFERASIROX IMMEDIATE RELEASE TABLETS
Authors :
Mohd Ismail Khalid Hashmi*, Dr.Y.Ganesh Kumar
Abstract :
Abstract:
The objective of this study is to formulate and significantly improve the bioavailability and reduce the side effects of immediate release tablets of Deferasirox. The precompression blends of Deferasirox were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicates well to fair flowability and compressibility. Immediate release tablets were prepared with various polymers like Croscarmellose sodium, Sodium starch glycolate and Crospovidone at different concentration ratios and were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The tablets were passed all tests. Among all the formulations F7 formulation containing, drug and Sodium starch glycolate showed good result that is 99.94 % in 45 min. Hence from the dissolution data it was evident that F7 formulation is the better formulation.
Keywords: Deferasirox, Immediate release, Croscarmellose sodium, Sodium starch glycolate, Crospovidone.
Cite This Article:
Please cite this article in press Mohd Ismail Khalid Hashmi et al., Preparation And Optimization Of Deferasirox Immediate Release Tablets, Indo Am. J. P. Sci, 2024; 11 (09).
Number of Downloads : 10
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