Volume : 11, Issue : 09, September – 2024
Title:
FORMULATION AND EVALUATION OF CONTROL RELEASED BUCCAL PATCHES OF PROPRANOLOL
Authors :
Mrs. Farheen Kouser*, Dr. Teelavath Mangilal, Mrs.T. Sowmya, Mr.K.Tharun Kumar, Miss.Afreen Banu.
Abstract :
Buccal drug delivery has been considered as an alternative to oral dosing for compounds subjected to degradation in the gastrointestinal tract or to hepatic first pass metabolism. Propranolol buccal patches were prepared by solvent casting technique using ethyl cellulose as baking membrane. . Propranolol buccal patches were prepared by using polymers like HPMC K15M,Guar gum, and karaya gum. Propylene glycol was used as plasticizer in the preparation of patches. Drug-excipients interaction studies (FTIR spectroscopy). The prepared patches will be evaluated for following parameter related to buccal drug delivery system like, a. Weight uniformity, b. Thickness. Folding endurance. Percentage swelling index,. Surface pH,of. Drug content estimation, g. Tensile strength,h. In- vitro drug release studies.In conclusion Propranolol buccal patches will be prepared to improve bioavailability and to avoid hepatic first pass metabolism. In all the cases the calculated standard deviation values are very low which they suggest that the prepared patches were uniform in weight. In all the cases the calculated standard deviation values are very low which suggest that, the prepared patches were uniform in thickness. From the result and conclusion of the research work we can summarize that propranolol can be delivered via buccal route.
Keywords: Propranolol, HPMC, K15M, Gaur gum, karaya gum, propylene glycol and ethyl cellulose.
Cite This Article:
Please cite this article in press Farheen Kouser et al., Formulation And Evaluation Of Control Released Buccal Patches Of Propranolol, Indo Am. J. P. Sci, 2024; 11 (09).
Number of Downloads : 10
References:
1. Jain N.K. Controlled and Novel Drug Delivery, 1st edition, published by CBS Publishers and Distributors, New Delhi. 1997; 52-81.
2.Shojaei AH. A systemic drug delivery via the buccal mucosal route, Pharm. Tech. 2001; 70-81.
3.Kharenko EA, Larionva NA, Demina NB. Mucoadhesive drug delivery system: quantitative assessment of interaction between synthetic and natural polymer films and mucosa. 2008; 42 (7): 17-24.
4.Patel VM, Prajapati BG, Patel MM. Design and characterization of chitosan containing mucoadhesive buccal patches of propranolol hydrochloride. Acta pharm. 2007; 57: 61-72.
5.Noha AN, Fatma AI, Boraie NA, Mortada LM. Mucoadhesive buccal patches of miconazole nitrate: in-vitro/ in-vivo performance and effect of aging. Int. J. pharm. 2003; 264: 1-14.
6.Amir H. Shojaei. Buccal mucosa as a route for systemic drug delivery: A review; J. Pharm. Sci.1998; 1 (1): 15-30.
7.Tora-Tora Derrikson principles of anatomy and physiology 2nd edition, edited by Bonnie Roech, Published by John wily and sons Inc. 2007; 902-08
8.Ross and Wilson. Anatomy and physiology in health and illness 9th edition edited by Anne Waugh and Alison Graw Published by Churchill Livingstone, Edinberg. 2001; 289-93.
9. Chatterjee CC. Human anatomy and physiology 10th edition Publishedby medical alliend agency, Calcutta 1985; 427-35.
10.Kharenko EA, Larionova NI, Demina NB. Mucoadhesive drug delivery system (review). Pharm. Chem. J. 2009; 43 (4): 200-09.
11. http://mota.stanford.edu/education/physics%2087N%20final%20Projects /Group%20Beta/drug03.htm.
12. Pharmaceutics the science of dosage form Design 2nd edition edited by M. E. Aulton. Published by Harcourt publishers Limited. 2002; 198-200.
13.Bristol-Myers Squibb Company, Syracuse. Oral cavity as a site for bioadhesivedrug delivery. Advanced drug delivery reviews, 1994; 13: 43-74.
14.Dominique Duchene and Gilles Ponchel. Bioadhesion of solid oral dosage form, why and how. Euro. J. Pharm. Biopharm. 1997; 44: 15-23.
15. Applied Biopharm. and pharmacokinetics 5th edition, edited by Leon Shargel . Published by M.C Grave hill companies 2005; 371-74.
16.Artusi M, Santi P Colombo P, Junginger HE. Buccal delivery of thiocolchicoside: in-vitro and in-vivo permeation studies. Int. J. Pharm. 2003; 250: 203-13.
17. Novel Drug Delivery system. 2nd edition, edited by James Swarbrick, Published by Marcel nokker Inc. 2007; 197-24.
18. Advances in controlled and Novel drug delivery and physiology 4th edition edited by Bonnie Roesch. Published by John wily and sons Inc.2007; 70-82.
19. Luana P, Valeria A, Fausta A, Maurizio R, Stefano G, Marinella C, Carlo R. Development of mucoadhesive patches for buccal administration of ibuprofen. J. Cont Rel. 2004; 99: 73-82.
20. Isabel Diaz, Francoise F, Richard HG, Yves J. Ex-vivo evaluation of bioadhesive films for buccal delivery of fenatyl. J. Cont Rel. 2007; 1-15.