Volume : 11, Issue : 09, September – 2024
Title:
FORMULATION AND CHARACTERIZATION OF TRANSDERMAL DRUG DELIVERY SYSTEM OF AMILORIDE
Authors :
Saleha, Dr Nazeemon
Abstract :
Objective: This study aims to develop and evaluate transdermal drug delivery systems (TDDS) for Amiloride, a potassium-sparing diuretic, employing various polymers like HPMC K100M, Polyvinyl Alcohol and Polyvinylpyrrolidone to enhance drug delivery efficiency, control release, and improve patient compliance.
Methods: Several formulations of Amiloride transdermal patches were developed using different polymers, including hydrogels, polyurethanes, and acrylics. The formulations were characterized based on their physical properties (e.g., thickness, mechanical strength, adhesive properties), drug release kinetics, and skin permeation rates. In vitro release studies were conducted using Franz diffusion cells.
Results: The study successfully formulated Amiloride transdermal patches with various polymers, each influencing the drug release profile and adhesive properties differently. Optimal formulations demonstrated controlled and sustained release of Amiloride, with some polymers providing superior performance in drug permeability and release rate.
Conclusion: The developed transdermal systems showed promise in enhancing the delivery and efficacy of Amiloride through controlled release mechanisms. The choice of polymer significantly impacted the performance of the transdermal patches, suggesting potential for improved patient compliance and therapeutic outcomes.
Keywords: Amiloride, HPMC K100M, Polyvinyl Alcohol and Polyvinylpyrrolidone
Cite This Article:
Please cite this article in press Saleha et al., Formulation And Characterization Of Transdermal Drug Delivery System Of Amiloride.,Indo Am. J. P. Sci, 2024; 11 (09).
Number of Downloads : 10
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