Volume : 11, Issue : 09, September – 2024
Title:
RECENT ADVANCEMENTS AND FUTURE TRENDS IN FAST DISINTEGRATING DRUG DELIVERY SYSTEM: A FOCUS ON NATURAL SUPERDISINTEGRANTS
Authors :
Bhavya Rai, Dr. Abadhesh Kumar Niranjan*
Abstract :
Fast disintegrating tablets (FDTs) represent a significant advancement in oral drug delivery systems, offering rapid disintegration and absorption without the need for water, thereby improving patient compliance. This review provides a comprehensive overview of FDTs, emphasizing their advantages, suitable drug candidates, and formulation strategies. A key focus is placed on natural superdisintegrants as sustainable alternatives to synthetic counterparts. Natural agents like starch, psyllium husk, and aloe vera demonstrate promising efficacy in enhancing tablet disintegration, aligning with the growing demand for eco-friendly excipients. The review further discusses the role of FDA-approved natural polymers and highlights patented technologies such as Zydis®, Orasolv®, and FlashDose® that drive innovation in FDT development. Additionally, various preparation methods—ranging from direct compression to lyophilization—are discussed, addressing their impact on disintegration times and tablet quality. The article also covers regulatory requirements for FDT approval, including stability and taste-masking considerations. Recent advancements, including 3D printing and nanotechnology, are explored as potential game-changers in personalized medicine and FDT manufacturing. Finally, future trends toward the expanded use of natural polymers, smarter FDT designs, and the broader application of these tablets in complex drug therapies.
Keywords: Fast disintegrating tablets, natural superdisintegrants, oral drug delivery, patented technologies, sustainable polymers
Cite This Article:
Please cite this article in Bhavya Rai et al., Recent Advancements And Future Trends In Fast Disintegrating Drug Delivery System: A Focus On Natural Superdisintegrants., Indo Am. J. P. Sci, 2024; 11 (09).
Number of Downloads : 10
References:
1. Rani, N., DEV, D.: Formulation and Evaluation of Fast Disintegrating Tablet of Propranolol Hydrochloride Using Modified Tamarind Seed Gum As a Natural Superdisintegrant. Asian J. Pharm. Clin. Res. 15, 185–192 (2022). https://doi.org/10.22159/ajpcr.2022.v15i9.45284
2. Rawooth, M., Habibullah, S.K., Qureshi, D., Bharti, D., Pal, A., Mohanty, B., Jarzębski, M., Smułek, W., Pal, K.: Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films. Polymers (Basel). 14, (2022). https://doi.org/10.3390/polym14142793
3. 3. Gowdu, R.S.: Formulation and Evaluation of Superdisintegrants on Diclofenac Tablets. 6, 167–192 (2021). https://doi.org/10.35629/7781-0605167192
4. 4. Pradhan, D., Chakraborty, P., Halder, S., Bagchi, A.: An overview on FDA-approved natural super disintegrants efficacy in a fast dissolving drug delivery system. J. Appl. Pharm. Res. 9, 1–7 (2021). https://doi.org/10.18231/j.joapr.2021.v9.i3.1-7
5. 5. Shobana, K., Subramanian, L., Rajesh, D.M., Sivaranjani, K.: A Review on Superdisintegrants. Int. J. Pharm. Sci. Rev. Res. 65, 149–154 (2020). https://doi.org/10.47583/ijpsrr.2020.v65i02.023
6. 6. Dawadi, S., Bipindra Pandey, Nepal, S., Gurau, Y., Shahi, R., Gautam, B., Akauliya, D., Pandit, M., Chaudhary, S., Adhikari Mahat, C.: Formulation and Evaluation of Orally Disintegrating Tablet of Metoclopramide Hydrochloride. World J. Curr. Med. Pharm. Res. 322–329 (2020). https://doi.org/10.37022/wjcmpr.vi.162
7. 7. Overview, A.N., Natural, O.N., Disintegrants, S., In, U., Tablet, F.D., Effects, T.: an Overview on Natural Super Disintegrants Used in. FDTs 9, 2657–2668 (2020). https://doi.org/10.20959/wjpr20207-18059
8. 8. Santosh Kumar, R., Kumari, A.: Superdisintegrant: crucial elements for mouth dissolving tablets. J. Drug Deliv. Ther. 9, 461–468 (2019). https://doi.org/10.22270/jddt.v9i2.2480
9. Bhusnure, O.G., et al. “Natural Superdisintegrants in Fast Disintegrating Tablets: A Comprehensive Review.” Journal of Pharmaceutical Research, vol. 11, no. 2, 2021, pp. 123-133.
10. Deshmukh, S.R., et al. “Superdisintegrants: An Emerging Excipient in Orally Disintegrating Tablets.” Journal of Pharmaceutical Sciences, vol. 9, no. 1, 2020, pp. 45-54.
11. Patil, B.R., et al. “Review on Natural Superdisintegrants for Fast Dissolving Tablets.” Indian Journal of Pharmaceutical Education and Research, vol. 53, no. 2, 2019, pp. 234-242.
12. Bhaskar Banger, Namdeo Shinde, Sunil Deshmukh, Birudev Kale, Natural polymers in drug delivery development, Research Journal of Pharmaceutical Dosage Forms and Technology. 2014; 6(1): 54-57.
13. Ikoni Joshua Ogaji, Elijah Irmiya Nep, Jennifer Audu-Peter, Advances in Natural Polymers as Pharmaceutical Excipients, Pharmaceutica Analytica Acta, January 2011; 3(1): 146, 2-16.
14. Radha Rani Earle, Lakshmi Usha Ayalasomayajula, G. Loknadh, K. Sai Ram Konda Reddy, L. Ratna Kanth, A Review on Natural Polymers Used in Pharmaceutical Dosage Forms, International Journal of Science and Research Methodology, 2016; 3(3): 77-88.
15. George Dan Mogoşanu Alexandru Mihai Grumezescu Ludovic Everard Bejenaru Cornelia Bejenaru, Natural and synthetic polymers for drug delivery and targeting, Nanobiomaterials in Drug Delivery Applications of Nanobiomaterials, 2016; 9: 229-284
16. Darveshwar Jagdeep D, Mule Madhav S, Birajdar Shivprasad M, Review on applications of polymers in pharmaceutical formulations, International Journal of Pharmaceutical Sciences, 2016; 2: 25-36.
17. Md Tausif Alam, Nayyar Parvez, and Pramod Kumar Sharma, FDA-Approved Natural Polymers for Fast Dissolving Tablets, Journal of Pharmaceutics Volume 2014, Article ID 952970, Pages:1-6.
18. Garima Yadav, Anupriya Kapoor and Shilpi Bhargava, Fast dissolving tablets recent advantages: A review, International Journal of Pharmaceutical Sciences and Research, 17 February 2012; 3(3): 728 -736.
19. Julie Mariam Joshua, R Hari, Fithal K Jyothish, Saritha A Surendran, Fast Dissolving Oral Thin Films: An Effective Dosage Form for Quick Releases, International Journal of Pharmaceutical Sciences, June 2016; Article No. 50, Pages: 282-289.
20. Rakesh Pahwa and Nisha Gupta, Superdisintegrants in the development of orally disintegrating tablet: A review, International Journal of Pharmaceutical Sciences and Research, 25 October 2011; 2(11): 2767-2780.
21. Ajay Kumar1 and Vikas Anand Saharan, A Comparative Study of Different Proportions of Superdisintegrants: Formulation and Evaluation of Orally Disintegrating Tablets of Salbutamol Sulphate, Turkish Journal of Pharmaceutical Science, 2017; 14(1): 40–48.
22. Ch. Saidulu, M. Jhansirani, R. Aruna, A.M.S. Sudhakar Babu, Formulation and evaluation of zolmitriptan fast dissolving tablet using synthetic superdisintegrants, International Journal of Pharmacy, 2014; 4(4): 365-370.
23. Sudhir Bharadwaj, Vinay Jain, Shailesh Sharma, R. C. Jat and Suman Jain, Orally Disintegrating Tablets: A Review, Drug Invention Today 2010; 2(1): 81-88.
24. J. Balasubramaniam, K. Bindu1, V. U. Rao, D. Ray, R. Haldar, and A. W. Brzeczko, Effect of Superdisintegrants on Dissolution of Cationic Drugs, International Specialty Product, May 2018; Pages:18-25.
25. Vimal V.V, Aarathi T.S, Anuja, Soumya Baby John, Superdisintegrants in fast disintegrating drug delivery systems: A brief review, International Journal of Pharmacy, 2013; 3(2): 380-385.
26. P. Srinarong J. H. Faber M. R. Visser W. L. J. Hinrichs H. W. Frijlink Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants, European Journal of Pharmaceutics and Biopharmaceutics (Elsevier), September 2009; 73(1): 154-161.
27. Vimal V.V, Aarathi T.S, Anuja, Soumya Baby John, Superdisintegrants in fast disintegrating drug delivery systems: A brief review, International Journal of Pharmacy, 2013; 3(2): 380-385.
28. Rakesh Pahwa and Nisha Gupta, Superdisintegrants in the development of orally disintegrating tablets: A review, 2011; 2(11): 2767-2780.
29. Deshmukh Himanshu et al, Superdisintegrants: A recent investigation and current approach, Asian Journal of Pharmacy and Technology, 2012; 2(1): 19-25.
30. Biswajit Basu, Abhishek Bagadiya, Sagar Makwana, Vora Vipul, Devraj Batt, and Abhay Dharamsi, Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material, Journal of Advanced Pharmaceutical Technology and Research, Oct-Dec 2018; 2(4): 266–273.
31. Ved Parkash, Saurabh Maan, Deepika, Shiv Kumar Yadav, Hemlata, and Vikas Jogpal, Fast disintegrating tablets: Opportunity in drug delivery system, Journal of Advanced Pharmaceutical Technology and Research, Oct-Dec 2011; 2(4): 223–235.
32. Chandrasekhar S, Superdisintegrants: A recent investigation and current approaches, Asian Journal of Pharmacy and Technology, 2012; 2(1): 19-25.
33. Rakesh Pahwa and Nisha Gupta, superdisintegrants in the development of orally disintegrating tablets: A review, International Journal of Pharmaceutical Sciences and Research, 25 October 2011; 2(11): 2767-2780.
34. Velmurugan S and Sundar Vinushitha, Oral Disintegrating Tablets: An Overview, International Journal of Chemical and Pharmaceutical Sciences 2010; 1(2): 1-12.
35. P. A. Hannan, J. A. Khan, A. Khan, and S. Safiullah, Oral Dispersible System: A New Approach in Drug Delivery System, Indian Journal of Pharmaceutical Science, Jan-Feb 2016; 78(1): 2-7.
36. Jie Wanga, Alvaro Goyanesab, Simon Gaisfordab, Abdul W. Basit, Stereolithographic (SLA) 3D printing of oral modified-release dosage forms, International Journal of Pharmaceutics (Elsevier), 30 April 2016; 503(1-2): 207-212.
37. Felipe J. O. Varum Hamid A. Merchant Abdul W. Basit, Oral modified-release formulations in motion: The relationship between gastrointestinal transit and drug absorption, International Journal of Pharmaceutics (Elsevier), 16 August 2010; 395(1-2): 26-36.
38. Pahwa and Nisha Gupta, superdisintegrants in the development of orally disintegrating tablets: A review, International Journal of Pharmaceutical Sciences and Research, 2011; 2(11): 2767-2780.
39. Vimal V V et al, Superdisintegrants in Fast Disintegrating Drug Delivery System: A brief review, International Journal of Pharmacy, 2013; 3(2): 380-385.
40. Satyajit Panda, Varadi Latha, Snigdha Pattnaik, Laxmidhar Maharana, Ranjit Prasad Swain, An Update on Various Excipients Employed for Orodispersible Tablets with A Special Focus on Superdisintegrants, International Journal of Pharmaceutical and Clinical Research 2015; 7(6): 440-449.
41. Vikas Sharma and Vandana Arora, comparison of various natural superdisintegrants in the formulation of fast dissolving carvedilol tablet, International Journal of Pharmaceutical Sciences and Research, 2012; Vol. 3(10): 3947-3954.
42. Nagar Praveen Kumar, Parvez Nayyar, Sharma Pramod Kumar, Superdisintegrants- current approach, Journal of Drug Delivery and Therapeutics; 2014; 4(3): 37-44.
43. Lavika Gandhi and Md. Semimul Akhtar, Formulation and Characterization of Mouth Dissolving Tablet of Antiepileptic Drug using Natural Superdisintegrants, Vol-9, NO 3-S (2019).
44. Md Tausif Alam, Nayyar Parvez, and Pramod Kumar Sharma, FDA-Approved Natural Polymers for Fast Dissolving Tablets, Journal of Pharmaceutics Volume 2014; Pages: 1-6.
45. P.S Mohanachandran, P.G Sindhumol, T.S Kiran, Superdisintegrants: an overview, International Journal of Pharmaceutical Sciences Review and Research, Article-022, January-February 2011; (6)1:105-109.
46. Sanyasi R. Kalidindi and Sanyasi R. Kalidindi, Evaluation of Soy Polysaccharide as a Disintegrating: Agent Part II: Wet Granulation, Drug Development, and Industrial Pharmacy, October 2008; 8(5): 631-650.