Volume : 11, Issue : 09, September – 2024
Title:
DESIGN AND EVALUATION OF COMPRESSION COATED TABLET OF METRONIDAZOLE FOR COLON-SPECIFIC DRUG DELIVERY SYSTEM
Authors :
Ravi Akkireddy, Rohit Saraswat, Srinivas L And Bhagheeradha L
Abstract :
The present study aims to formulate colon-targeted drug delivery of metronidazole compression-coated tablets using different ratios of chitosan and pectin. The core tablets of metronidazole (400 mg) were prepared using swellable and pH-dependent polymers like chitosan and pectin, and PVP-K30 was used as a binder. The compression-coated tablets containing chitosan as a polymer released 95-99% of metronidazole in simulated colonic fluid, whereas tablets containing pectin released 94-99% of metronidazole. The stability study for prepared tablets at 40°C/75% relative humidity for 6 weeks showed no significant change in physical appearance, drug content uniformity and in vitro drug release pattern. The result indicates that formulations F4 and F8 were suitable for colonic drug delivery as drug release is maximum compared to other formulations.
Keywords: Colon drug delivery system, Chitosan, Pectin, Compression Coating, and Metronidazole
Cite This Article:
Number of Downloads : 10
References:
1. Bhushan Prabhakar Kolte.; Colon Targeted Drug Delivery System – A Novel Perspective. Asian journal of biomedical and pharmaceutical sciences, 2012; 2(14): 1- 10.
2. Danda Sreelatha and Chandan Kumar Brahma. Colon Targeted Drug Delivery A Review on Primary and Novel Approaches. Journal of Global Trends in Pharmaceutical Sciences, 2013; 4(3): 1174-1183.
3. Gannu Praveen kumar and Bakka Sravan Kumar. Colon specific delivery systems: The local drug targeting‖ Drug Invention Today, 2011; 3(10): 227-234.
4. Yangchao Luo and Qin Wang. Recent development of chitosan-based polyelectrolyte complexes with natural polysaccharides for drug delivery. International Journal of Biological Macromolecules, 2014; 64 (1): 353-367.
5. Singh Sandeep Kumar and Singh Abhishek Kumar. Formulation and Evaluation of an Anti-Amoebic Drug (Tinidazole) of Colon Targeted Drug Delivery. International Journal of Research Article Pharmaceutical Innovations, 2016; 2(2): 138-152.
6. Prasanta Kumar Choudhury, Padala Narasimha Murthy, Niraj Kanti Tripathy, B. Sanuja Patra. Formulation Design and Development of Enteric Coated Matrix Tablets Of Ornidazole For Colonic Delivery. Asian Journal Of Pharmaceutical And Clinical Research, 2012; 5(3): 86-89.
7. Tarak J. Mehta, Satyanarayan Singh Rajput, Mukesh R. Patel, Kanu R.Patel, Natvarlal M. Patel and Mohan Mothila. Formulation, Development and Optimization of Metronidazole Compression Coated Tablets, Scholars Research Library, Der Pharmacia Lettre, 2011; 3(5): 94-103.
8. Gauri Bhawna1, Singh Shailendra. K and Mishra Dinanath. Formulation and Evaluation of Colon Targeted Oral Drug Delivery Systems for Metronidazole in Treatment of Amoebiasis. International Journal of Drug Delivery, 2011; 3(1): 503-512.
9. M. Praveen Kumar, B. Mohammed Ishaq, J. Ravi Kumar Reddy, R. Pradeep Kumar, C. Madhusudhana Chetty. Formulation and Evaluation of Colon Specific Matrix and Coated Tablets of Metronidazole. International research journal of pharmacy, 2011; 2(9), 194-199.
10. Bala venkat, Pradeep.V, Grace Ratnam. Development of enteric-coated pectin matrix tablets of metronidazole for colon targeting. International journal of pharmaceutical research and development, 2011;3(6), 10-16.
11. S. C. Dhawale, A. S. Bankar, M. N. Patro. Formulation and Evaluation of Porous Microspheres of 5-Fluorouracil for Colon Targeting. International Journal of PharmTech Research, 2010;2(2), 1112-1118.
12. Chickpetty S. M. and Raga Baswaraj. Studies on Design and In Vitro Evaluation of Compression-Coated Delivery Systems for Colon Targeting of Diclofenac Sodium‖. International Journal of PharmTech Research, 2010; 2(3), 1714-1722.
13. Patel Jayvadan K, Patel Nirav V, Shah Shreeraj H. Formulation And In-Vitro Evaluation Of Mesalamine Matrix Tablets Using Chitosan For Colonic Drug Delivery‖ Journal Of Pharmacy Research, 2009; 2(8), 1319-1323.
14. Man Han Min Han, Qiu-Li Fang, Hong-Wei Zhan, Tao Luo, Wen-Quan Liang, Jian- Qing Gao. In Vitro and In Vivo Evaluation of a Novel Capsule for Colon- Specific Drug Delivery‖ Journal of Pharmaceutical Sciences, 2009; 98(8):1-10.
15. D Nagasamy Venkatesh, Ajay Kumar Reddy, M K Samanta, B Suresh. Development and in vitro evaluation of colonic drug delivery systems for tegaserod maleate. Asian Journal of Pharmaceutics, 2009; 5(1): 50-53.
16. Kishor Sahebrao Salunkhe and Mohan Vinayak Kulkarni. (2008). Formulation and In Vitro Evaluation of Dextrin Matrix Tablet of Ibuprofen for Colon Specific Drug Delivery. Pakistan Journal of Pharmaceutical Sciences, 21(1): 17-20.
17. M A Nasra M. A. Nasra, M. A. EL-Massik, and V. F. Naggar. Development of Metronidazole Colon-Specific Delivery Systems. Asian Journal of Pharmaceutical Sciences, 2007; 2 (1), 18-28.
18. Shaik Shabbeer and Sudha Madhuri. Formulation and Development of Mesalamine Sustained Release Guar Gum Matrix for Colon-Specific Drug Delivery. International Journal of Pharmaceutical Research and Development, 2012,4(02), 180-185.
19. Biraju D. Patel, Dhaval V. Patel, Jayant R. Chavda, Mahesh R. Dabhi and Ravi A. Manek. Development and evaluation of pectin-based colon targeted herbal drug delivery system. African Journal of Pharmacy and Pharmacology, 2012; 6(25), 1815-1820.
20. Y.S.R Krishnaiah, P Veer Raju, B Dinesh Kumar, P Bhaskar, V Satyanarayana. Development of colon targeted drug delivery systems for mebendazole. Journal of Controlled Release, 2001;77(1–2): 87–95.