Volume : 11, Issue : 09, September – 2024
Title:
REVIEW ON THE GC-MS ANALYSIS OF ESSENTIAL OIL OF EUPATORIUM TRIPLINERVIS VAHL, ASTERACEAE
Authors :
Dhanya A S* , Ajitha H S
Abstract :
Eupatorium triplinervis, a tropical plant belonging to the family Asteraceae has been employed in traditional medicine for its diverse therapeutic properties. The review will provide an in-depth examination of Chemical composition and variability of E. triplinervis essential oil and leaf extracts like petroleum ether, n- hexane, acetone, ethanol and methanol. The retention time and peaks that corresponds to the bioactive compound identified and the biological activity and inhibitory properties (Pa and Pi) values of the compounds found in the various solvent leaf extracts varies in their different biological activities ranging from cytotoxicity, anti-bleeding, inflammation, itching, and intra-abdominal pressure evaluated by literature search. The analysis estimates anti-inflammatory, astringent, anti-hemorrhagic, antinephritic, antifibrinolytic, antispasmodic activity, and other biological activities to express structural predicted target site for drug design and serves as a beneficial tool to assess the compounds, their side effects, and toxicity. The yield of essential oil typically ranges from 0.5-2.5% (v/w) with a pale yellow – green colour. GC-MS analysis revealed the presence of 90 compounds including sesquiterpenes (α-caryophyllene, β-caryophyllene), monoterpenes (limonene, β-pinene), and phenolic compounds (eugenol, vanillin). Petroleum ether extract showed maximum number of compounds and least was for n-hexane leaf extract. Pharmacological activities, including antimicrobial, anti-inflammatory, antioxidant, and antipyretic effects, were correlated with the identified phytochemicals. PharmaExpert, was used to analyze pharmacological potential of major constituents. By consolidating the current knowledge on E. triplinervis, this review seeks to stimulate further research into its untapped pharmacological potential and promote its development as a natural remedy for various health conditions.
Keywords: Eupatorium triplinervis, GC-MS profiling, phytochemical constituents, pharmacological implications, essential oil, extracts.
Cite This Article:
Please cite this article in press Dhanya A S et al., Review On The GC-MS Analysis Of Essential Oil Of Eupatorium Triplinervis Vahl, Asteraceae., Indo Am. J. P. Sci, 2024; 11 (09).
Number of Downloads : 10
References:
1. Singh DK, Kumar V, Mahapatra SK. Eupatorium triplinervis Vahl: A Review of its Pharmacological and Therapeutic Applications. Journal of Pharmacy and Pharmacology. 2018; 70(8): 1111-1123.
2. Bilia AR, Guccione C, Isacchi B. Essential oils and their constituents: GC-MS analysis and pharmacological properties. Journal of Pharmacy and Pharmacology. 2018; 70(8): 1083-1095.
3. Garg, S. C., & Nakhare, S. (1993). Studies on the essential oil from the flowers of Eupatorium triplinerve. Indian Perfumer, 37, 318.
4. Gauvin-bialecki, A., & Marodon, C. (2009). Essential oil of Ayapana triplinervis from Reunion Island : A good natural source of thymohydroquinone dimethyl ether. Biochemical Systematics and Ecology, 36(11), 853–858. https://doi.org/10.1016/ j.bse.2008.09.006.
5. Matos Lopes, T. R., de Oliveira, F. R., Malheiros, F. F., de Andrade, M. A., Monteiro, M. C., & Baetas Gonçalves, A. C. (2015). Antimicrobial bioassay-guided fractionation of a methanol extract of Eupatorium triplinerve. Pharmaceutical Biology, 53(6), 897–903. https://doi.org/10.3109/13880209. 2014.948634
6. Nisha, K., Darshana, M., Madhu, G., & Bhupendra, M. K. (2011). GC-MS analysis and anti-microbial activity of Psidium guajava (leaves) grown in Malva region of India. Int J Drug Dev Res, 3(4), 237–245.
7. Patel, D. K. (2022). Health Beneficial Aspect and Therapeutic Potential of Cirsimaritin in the Medicine for the Treatment of Human Health Complications. Current Bioactive Compounds, 18(7), 27–38.
8. Ponnamma, S. U., & Manjunath, K. (2012). GC- MS analysis of phytocomponents in the methanolic extract of Justicia wynaadensis (Nees) T. anders. International Journal of Pharma and Bio Sciences, 3(3), 570–576.
9. Rao, C. V, Newmark, H. L., & Reddy, B. S. (1998). Chemopreventive effect of squalene on colon cancer. Carcinogenesis, 19(2), 287–290.
10. Redfern, J., Kinninmonth, M., Burdass, D., & Verran, J. (2014). Using Soxhlet Ethanol Extraction to Produce and Test Plant Material (Essential Oils) for Their Antimicrobial Properties. Journal of Microbiology & Biology Education, 15(1), 45–46. https://doi.org/10.1128/jmbe.v15i1.656.
11. Scortichini, M., & Rossi, M. P. (1991). Preliminary in vitro evaluation of the antimicrobial activity of terpenes and terpenoids towards Erwinia amylovora (Burrill) Winslow et al. Journal of Applied Bacteriology, 71(2), 109–112. https://doi.org /10.1111/j.1365-2672.1991.tb02963.x.
12. Selvamangai, C., & Bhaskar, A. (2012). Available online http://www.ijddr.in Covered in Official Product of Elsevier , The Netherlands SJR Impact Value 0 . 03 & H index 2 © 2012 IJDDR GC-MS Analysis of Phytocomponents in the Methanolic Extract of Eupatorium triplinerve. 4(4), 148–153.
13. Starlin, T., Arul, R. C., Ragavendran, P., & Gopalakrishnan, V. K. (2012). Phytochemical screening, functional groups and element analysis of Tylophora pauciflora wight and arn. Int Res J Pharm, 3(6), 180–183.
14. Sugumar, N., Karthikeyan, S., & Gowdhami, T. (2015). Phytochemical analysis and antimicrobial activity of Eupatorium triplinerve Vahl. 1(12), 108– 112.
15. Sunitha, S., Nagaraj, M., & Varalakshmi, P. (2001). Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defence system in cadmium-induced hepatotoxicity in rats. Fitoterapia, 72(5), 516–523.
16. Ukiva, M. (2002). Antitumor promoting effects and cytotoxic activity against human cancer liners of triterpene diols and triols from edible Chrysanthemum flowers. Cancer Lett., 177, 7–12.
17. Uma, B., Prabhakar, K., Rajendran, S., & LAKSHMI, S. Y. (2009). Studies on GC/MS spectroscopic analysis of some bioactive antimicrobial compounds from Cinnamomum zeylanicum. 32. Vahl, T. (2016). international journal of universal “analgesic activity of hydro alcoholic extracts of stems and roots of eupatorium.
18. Varghese, B., Sr, C., Sr, P. K., Jr, J. N., & Shanmugasundaram, J. (2017). Anti-nociceptive Effect of 7-methoxy Coumarin from Eupatorium triplinerve Anti-nociceptive Effect of 7-methoxy Coumarin from Eupatorium triplinerve vahl (Asteraceae ). https://doi.org/10.4103/ 0973-1296.197650