Volume : 11, Issue : 09, September – 2024
Title:
DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM FOR THE MANAGEMENT OF PEPTIC ULCER
Authors :
Minakshi S. Lothe., S.T.Thoke., U.T. Jadhao., D.A.Rathod. ,G.N.Dhembre., S.A.Wathore.
Abstract :
The aim of the study was the formulation of the floating matrix tablet of clarithromycin The floating tablet of Clarithromycin was prepared by wet-granulation method. The tablets were formulated using hydrophilic polymer HPMC K15M and HPMC K100M, along with an effervescent agent such as sodium bicarbonate. Preformulation compatibility studies indicate that there is no interaction between the excipient and the drug. Total eight batches were prepared and powder blends before compression was subjected for evaluation of flow properties. All the parameter was found to be within the limit showing good flow property. all batch was evaluated for thickness, hardness, friability, weight variation, drug content uniformity, swelling index, buoyancy studies, invitro release pattern. The thickness of tablet indicates that die fill was uniform in all the formulation and the formulation possessed sufficient hardness & friability indicating a good mechanical strength of the development formulation. The weight of the all the formulation were found to be with in pharmacopeial limit. The invitro dissolution profile of all the formulation of Clarithromycin was controlled over an extended period of time. The optimized formulation of F8 containing combination of HPMC K15M, HPMC K100M was consider as the best formulation with respect to its lower floating lag time, sustained in vitro drug release for 12 hrs, total floating time & improved bioavailability & site specific action. The developed formulation was found to be stable during the stability studies of 3 month indicating good stability of the tablets
Keywords: Clarithromycin, H-pylori infection, floating time, stability studies.
Cite This Article:
lease cite this article in press Sandip T.Thoke et al., Development And Evaluation Of Gastroretentive Floating Drug Delivery System For The Management Of Peptic Ulcer., Indo Am. J. P. Sci, 2024; 11 (09).
Number of Downloads : 10
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