Volume : 11, Issue : 09, September – 2024
Title:
SILICA H2SO4 AS AN EFFICIENT HETEROGENEOUS CATALYST FOR THE SYNTHESIS OF NEW COUMARIN DERIVATIVES AND EVALUATION OF ANTIBACTERIAL ACTIVITY
Authors :
Siva Jyothi Buggana*, Anem Nnawyaa. Gunnala Srinidhi, Indira Rani N
Abstract :
The literature survey indicates that benzopyran derivatives possess different pharmacological and biological activities. Coumarin derivatives have been shown to have interesting pharmacological activities such as antibacterial, anti-inflammatory, and antifungal activities. When one biologically active molecule is linked to another, the resultant molecule generally has an increased potency. Therefore, in the present study, two systems of Coumarin and chalcone are fused to obtain highly potent, specifically anti-inflammatory and less toxic antibacterial agents. The objective of the present work is to synthesize chalcone-substituted Coumarin derivatives and in particular study their antibacterial properties. The paper makes a modest attempt in that direction. Coumarin derivatives were synthesized using SSA as a potent catalyst. All the synthesized derivatives were characterized by 1H1 NMR, Mass spectra, and I.R. spectra. The antibacterial activity of the compounds was carried out using the disc diffusion method on nutrient agar media. Ampicillin and Gentamycin were used as standard drugs for the comparison in the concentration of 50 µg/ml and 100 µg/ml against Gram-positive and Gram-negative bacteria used for the study. Compounds 3g,3i, and 3j were found to possess good activity while compounds 3a, 3b, 3c, 3d, 3e, and 3f, were found to exhibit moderate activity. Among these various compounds 3g, 3i, and 3j particularly exhibited good activities against gram-negative bacteria. Hence, these compounds appear to be promising anti-bacterial agents. Perhaps the presence of N(CH3)2 and OH as a substituent on the aromatic nucleus attached to the 4th position attached to Coumarin nucleus at the 3rd may be responsible for the good anti-bacterial activity.
Key words: Silica Sulphuric Acid Catalyst, Disc Diffusion Method, Antibacterial Activity, Coumarin, Chalcones
Cite This Article:
Please cite this article in press Buggana Siva.Jyothi et al., Silica H2so4 As An Efficient Heterogeneous Catalyst For The Synthesis Of New Coumarin Derivatives And Evaluation Of Antibacterial Activity, Indo Am. J. P. Sci, 2024; 11 (09).
Number of Downloads : 10
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Volume : 11, Issue : 09, September – 2024
Title:
THE EFFECT OF EQUIPPING AMBULANCES WITH RAPID COMMUNICATION MECHANISMS IN RESPONDING QUICKLY TO THE INJURED IN EMERGENCY SITUATIONS
Authors :
Zaher Ali Awadh Alshehri., MADINE MNAJI MOHAMMED ALSHAREIF . Yasser Yahya Amer Alhabis ., Mohammed Abdullah Awwadh Al-Harthi., Mohammed Mnaji Mohammed Alshareif., Othman Mabruk Faraj Alotaibi., Marzouq Masad Bin Hamdan Alhathla.
Abstract :
The current study aimed to identify the impact of equipping ambulances with rapid communication mechanisms on the response time for injured individuals in emergency situations. This was achieved by employing a descriptive analytical approach through the distribution of a questionnaire consisting of 500 emergency medical technicians to assess their opinions regarding the equipping of ambulances and rapid communication mechanisms. The study’s results indicated that there was no statistical significance attributed to professional and occupational experiences or the number of years of service concerning the responses of the sample on the questionnaire. The study presented several findings, including that technological advancements have facilitated the provision of higher quality communication means in ambulances, ensuring various solutions for rapid access to victims in emergencies. Furthermore, the implementation of precise location identification technology has enhanced response speed and helped avoid traffic congestion. The study’s results also indicated that the quicker the access to the accident scene, the greater the chances of survival for the injured, and that there is an effect of delayed response on rescue opportunities.
Key words: Technique, technology, response speed, communication methods, rapid access methods.
Cite This Article:
Please cite this article in press Zaher Ali Awadh Alshehri et al., The Effect Of Equipping Ambulances With Rapid Communication Mechanisms In Responding Quickly To The Injured In Emergency Situations, Indo Am. J. P. Sci, 2024; 11 (09).
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