Volume : 12, Issue : 04, April – 2025
Title:
PHARMACOLOGICAL SCREENING OF ANTI HELMINTIC ACTIVITY, ANTI BACTERIAL ACTIVITY AND ANTI OXIDANT OF CANTHIUM COROMANDELICUM
Authors :
Kondumahanti V. N. Lakshmi, Dr. D. Narendra, P. Sunanda, P. Jaya Prasanna, P. Naga Madhavi Latha, P. Kamala Sai Sireesha
Abstract :
Day by day helminthiasis and bacterial infections were increasing globally. The major aim of the study is to investigate preliminary phytochemical screening, anti-bacterial, antioxidant and anti-helminthic activity of different extracts of Canthium coromandaelicum. Preliminary phytochemicals analysis of the extract showed the presence of alkaloids, flavonoids, saponins, and taninns. The evaluation of the anti-helminthic activity is done by using the adult Indian earthworms (Pheritima posthumas it has similar anatomical and physical resemblance of intestinal round worm. The different concentrations of different extracts (Ethanolic Extract, Methanolic Extract and Aqueous alcoholic extract of Canthium coromandelicum) is compared to standard Piperazine Citrate. And then the time for paralysis and time taken for death of the worms were noted. The Present Study is designed to evaluate the Protective effects of different extracts of Canthium Coromendalicum against various activities like Anti-oxidant activities, Anti-bacterial and antihelminthic activity. Evaluation of the anti-bacterial activity was done by cup plate method at different concentrations (25mg/ml, 50mg/ml, 75mg/ml and 100mg/ml) of extract and the results were compared with gentamycin (standard antibiotic). After 48hrs we observed the zone of inhibition. By zone of inhibition, it was proved that it is having the good anti-bacterial activity. As well as the Antioxidant Activity was proved by DPPH Assay. DPPH scavenging activity of plant extract (IC50 13µg/ml) showed IC50 value close to the ascorbicacid(15µg/ml). Ethanolic extract has showed better effects than Aqueous alcholic extract and methanolic extract in Antioxidant Study..
KEYWORDS: Canthium coromandelicum, anti-bacterial activity, anti-helminthic activity, preliminary phytochemical screening, anti-oxidant activity.
Cite This Article:
Please cite this article in press Kondumahanti V. N. Lakshmi et al., Pharmacological Screening Of Anti Helmintic Activity, Anti Bacterial Activity And Anti Oxidant Of Canthium Coromandelicum., Indo Am. J. P. Sci, 2025; 12(04).
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