Volume : 12, Issue : 04, April – 2025
Title:
NEUROPHARMACOLOGICAL SCREENING OF ANTIDEPRESSANT AND ANTISTRESS ACTIVITY OF ACACIA NILOTICA LINN LEAVES EXTRACT.
Authors :
Mohd Ismail Zubair*, Pawan kumar, Syed Saifullah Ghori, Syed Fayyazuddin, Syed Azhar ullah Quadri, Md Zubair Ahmed, Md Shoaibuddin Khateeb
Abstract :
Objective: The current study was designed to explore Neuropharmacological screening of antidepressant and antistress activity of leaves extract Acacia Nilotica in albino wistar rat.
Materials and Methods: Behavioral procedures of depression and Stress were assessed in rats. A methanolic extract of Acacia Nilotica leaves with dose ranges of 100, 200, and 400 mg/kg was given once a daily for 7 days via oral route and the efficacy was matched by those elicited by lorazepam (1 mg/kg, p.o.), imipramine (10 mg/kg, p.o.) and Withania somnifera (100 mg/kg, p.o.) for antidepressant, and antistress studies, respectively. Standard drugs were given 1 time, 30 min preceding the behavioral trials. Results: One-way analysis of variance followed by Newman–Keuls multiple comparison test was employed to analyze the results. P < 0.05 was considered statistically significant as compared to control. AN at 400 mg/kg also induced an antidepressant activity similar to imipramine, in the behavioral despair, learned helplessness test, and tail suspension among selected doses of the AN. More over AN at 400 mg/kg produced a significant antistress effect comparable to Withania somnifera in water immersion-restraint stress by decreasing ulcer index, adrenal gland weight, and by normalizing the plasma levels of corticosterone, glucose, cholesterol, and triglyceride levels when related to stress control.
Conclusion: The study shows that among the different AN dose, AN at 400mg/kg possesses significant antidepressant and anti-stress effects has therapeutic beneficial for the management of psychological ailments.
Keywords: Antidepressant, Antistress, Acacia Nilotica, Ulcer index, Withania somnifera
Cite This Article:
Please cite this article in press Mohd Ismail Zubair et al., Neuropharmacological Screening Of Antidepressant And Antistress Activity Of Acacia Nilotica Linn Leaves Extract., Indo Am. J. P. Sci, 2025; 12(04).
Number of Downloads : 10
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