Volume : 12, Issue : 04, April – 2025
Title:
NEUROPHARMACOLOGICAL SCREENING OF ANTI-DEPRESSANT AND ANTI-STRESS ACTIVITY OF TERMINALIA CORIACEA (ROXB.) WIGHT AND ARN. LEAVES EXTRACT
Authors :
Mohd Ismail Zubair*, Pawan kumar, Syed Saifullah Ghori, Syed Fayyazuddin, Syed Azhar ullah Quadri, Md Zubair Ahmed, Md Shoaibuddin Khateeb
Abstract :
Objective: The current study was designed to explore Neuropharmacological screening of antidepressant and antistress activity of leaves extract Terminalia Coriacea in albino wistar rat.
Materials and Methods: Behavioral procedures of depression and Stress were assessed in rats. A methanolic extract of T. coriacea leaves with dose ranges of 100, 200, and 400 mg/kg was given once a daily for 7 days via oral route and the efficacy was matched by those elicited by lorazepam (1 mg/kg, p.o.), imipramine (10 mg/kg, p.o.) and Withania somnifera (100 mg/kg, p.o.) for antidepressant, and antistress studies, respectively. Standard drugs were given 1 time, 30 min preceding the behavioral trials.
Results: One-way analysis of variance followed by Newman – Keuls multiple comparison test was employed to analyze the results. P < 0.05 was considered statistically significant as compared to control. TC at 400 mg/kg also induced an antidepressant activity similar to imipramine, in the behavioral despair, learned helplessness test, and tail suspension among selected doses of the TC. Moreover, TC at 400 mg/kg produced a significant antistress effect comparable to Withania. somnifera in water immersion-restraint stress by decreasing ulcer index, adrenal gland weight, and by normalizing the plasma levels of corticosterone, glucose, cholesterol, and triglyceride levels when related to stress control.
Conclusion: The study shows that among the different TC doses, TC at 400mg/kg possesses significant antidepressant and anti-stress effects has therapeutic beneficial for the management of psychological ailments.
Keywords: Antidepressant, Antistress, Terminalia Coriacea, Ulcer index, Withania somnifera
Cite This Article:
Please cite this article in press Mohd Ismail Zubair et al., Neuropharmacological screening of antidepressant and antistress activity of terminalia coriacea (roxb.) Wight and arn. Leaves extract., Indo Am. J. P. Sci, 2025; 12(04).
Number of Downloads : 10
References:
2. Bangasser DA, Curtis A, Reyes BA, Bethea TT, Parastatidis I,Ischiropoulos H, et al. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: Potential role in female vulnerability to stress-related psychopathology. MolPsychiatry2010;15:877,896-904.
3. CottJ. NCDEU update. Natural product formulations available in europe for psychotropic indications. Psychopharmacol Bull 1995;31:745-51.
4. Chakraborty U, Das H. Antidiabetic and antioxidant activities of Terminalia Coriacea leaf extracts in Stz-treated diabetic rats. GlobJ Biotechnol Biochem 2010;5:12-8.
5. Dhulasavant V, ShindeS, Pawar M, Naikwade NS. Antihyperlipidemic activity of Cinnamomum tamala Nees, on high cholesterol diet induced hyperlipidemia. Int J PharmTech Res 2010;2:2517-21.
6. Eswaran MB, Surendran S, Vijayakumar M, Ojha SK, Rawat AK,Rao ChV. Gastroprotective activity of Cinnamomum tamala leaves on experimental gastric ulcers in rats. J Ethnopharmacol 2010;128:537-40.
7. Singh B, Chandan BK, Sharma N, Singh S, Khajuria A, Gupta DK. Adaptogenic activity of glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaerten (part II).Phytomedicine 2005;12:468-81.
8. Vijayalakshmi, Adiga S, Bhat P, Chaturvedi A, Bairy KL, Kamath S. Evaluation of the effect of Ferulaasa foetida Linn. Gum extract on learning and memory in Wistar rats. Indian J Pharmacol 2012;44:82-7.
9. Yadav AV, Kawale LA, Nade VS. Effect of Morus alba L.(mulberry) Leaves on anxiety in mice.Indian J Pharmacol 2008;40:32-6.
10. File SE, Hyde JR. Can social interaction be used to measure anxiety? Br J Pharmacol 1978;62:19-24.
11. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice:A
Primary screening test for antidepressants. Arch Int Pharmacodyn Ther 1977;229:327-36.
12. Bourin M, Chenu F, Ripoll N, David DJ. A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests. Behav Brain Res 2005;164:266-9.
13. Seligman ME, Beagley G. Learned helplessness in the rat. JComp Physiol Psychol 1975;88:534-41.
14. Nishida K, Ohta Y, K obayashi T, Ishiguro I. Involvement of the xanthine-xanthine oxidase system and neutrophils in the development of acute gastric mucosal lesions in rats with water immersion restraint stress. Digestion 1997;58:340-51.
15. Wood ward C J, Emery P W. Determination of plasma corticosterone using high-performance liquid chromatography. J Chromatogr1987; 419:280-4.
16. Cryan JF, Sweeney FF. The age of anxiety: Role of animal models of anxiolytic action in drug discovery. BrJPharmacol 2011; 164:1129-61.
17. Wada T, Nakajima R, Kurihara E, Narumi S, Masuoka Y, Goto G, et al. Pharmacologic characterization of a novel non-benzodiazepine selective anxiolytic, DN-2327. Jpn J Pharmacol1989; 49:337-49.
18. Radley JJ, Kabbaj M, Jacobson L, Heydendael W, Yehuda R, Herman JP. Stress risk factors and stress-related pathology: Neuroplasticity, epigenetics and endophenotypes. Stress 2011;14:481-97.
19. SelyeH.A syndrome produced by diverse nocuous agents1936.
JN euro psychiatry ClinNeurosci1998;10:230-1.
20. Sardessai SR, Abraham ME, Mascarenhas JF. Effect of stress on Organ weight in rats. Indian J PhysiolPharmacol 1993;37:104-8.
21. Bharadwaj DK, ChandG, GuptaAK, JainRK. Polyphenolic component of C.tamala.Proc Indian Nat lSci A cad 1983;49:413-7.
22. SinghVP,PandeyR,YadavB,PandeyVB.Flavonoidsof
Terminalia Coriacea.NatProdSci 2002;8:16-7.
23. Höferl M, Krist S, Buchbauer G. Chirality influences the effects of linalool on physiological parameters of stress. Planta Med2006;72:1188-92.
24. Linck VM, da Silva AL, Figueiró M, Piato AL, Herrmann AP,DupontBirckF,etal.Inhaledlinalool-inducedsedationinmice.Phytomedicine2009;16:303-7.
25. Vissiennon C, Nieber K, Kelber O, Butterweck V. Route ofadministration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin–Are they prodrugs? J Nutr Biochem 2012; 23:733-40.