Volume : 12, Issue : 04, April – 2025
Title:
ANTI-ANXIETY AND NOOTROPIC ACTIVITY OF CARALLUMA FIMBRIATA EXTRACT IN ALBINO WISTAR RATS
Authors :
Syed Fayyazuddin*, Pawan Kumar, Syed Safiullah Ghori ,Mohd Ismail Zubair, Syed Azhar Ullah Quadri, Md. Zubair Ahmed, Md Shoaibuddin Khateeb*.
Abstract :
Objective: The current investigation was planned to assess Anti-anxiety and Nootropic activity of aqueous and ethanol extracts of Caralluma fimbriata. in Albino wistar rats.
Methods: Anti-anxiety of aqueous and ethanolic extracts of Caralluma fimbriata was appraised by adaptogenic activity in rats through the forceful swimming. Biochemical parameters such as 6-β-OH-cortisol, urinary vanilly mandelicacid (VMA), homovanillic acid (HVA), ascorbic acid and 5-hydroxy indole acetic acid (5HIAA) were estimated to analyze the anti-anxiety activity. Aqueous and ethanolic extracts of Caralluma fimbriata were administrated orally at dose of 200 and 400mg/kg body weight 1h before the induction of anxiety to prevent anxiety-induced urinary biochemical changes in a dose dependent manner. Behavioral procedures of anxiety and cognitive-enhancing were assessed in rats. A ethanolic extract of C. fimbriata with dose ranges of 100, 200, and 400 mg/kg was given once a daily for 7 days via oral route and the efficacy was matched by those elicited by lorazepam (1 mg/kg, p.o.), imipramine (10 mg/kg, p.o.) and Withania somnifera (100 mg/kg, p.o.) for antianxiety, and nootropic studies, respectively. Standard drugs were given 1 time, 30 min preceding the behavioral trials.
Results: Nevertheless, in all groups which were treated with aqueous and ethanolic extracts of Caralluma fimbriata, there was no statistically difference between level of 6-β-OH-cortisol, urinary vanillymandelic acid (VMA), homovanillic acid (HVA), ascorbic acid and 5-hydroxyindoleacetic acid (5HIAA) as compared to normal animals. One-way analysis of variance followed by Newman–Keuls multiple comparison test was employed to analyze the results. P < 0.05 was considered statistically significant as compared to control. CF at 400 mg/kg also induced an antianxiety activity similar to imipramine, in the behavioral despair, learned helplessness test, and tail suspension among selected doses of the CF. Moreover, CF at 400 mg/kg produced a significant nootropic effect.
Conclusion: The study shows that among the different CF doses, CF at 400mg/kg possesses significant antianxiety and nootropic effects has therapeutic beneficial for the management of psychological ailments.
Keywords: adaptogenic activity, Caralluma fimbriata, biochemical parameters.
Cite This Article:
Please cite this article in press Syed Fayyazuddin et al., Anti-Anxiety And Nootropic Activity Of Caralluma Fimbriata Extract In Albino Wistar Rats., Indo Am. J. P. Sci, 2025; 12(04).
Number of Downloads : 10
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