Volume : 12, Issue : 04, April – 2025

Title:

THERAPEUTIC APPLICATION OF ASPARAGUS RACEMOSUS IN DEPRESSION: A REVIEW

Authors :

Akshaya. P*, Mrs. Anusree. S , Mrs.Rupitha. N S , Ms. Liya S Saji , Dr. Kiran K J, Dr. Prasobh G.R

Abstract :

Asparagus racemosus also known by the name Shatavari is one of the well-known drugs in Ayurveda, belonging to family Asparagaceae. This herb is highly effective in problems related with female reproductive system. Asparagus racemosus is a well-known Ayurvedic rasayana which prevent ageing, increase longevity, impart immunity, improve mental health. Depression is a mental health condition that causes a persistant feeling of sadness and loss of interest in activities. Asparagus racemosus contains numerous steroidal saponins, alkaloids, flavonoids, tannins. Due to the presence of these chemical constituents the plant shows neuroprotective, antitussive, immunomodulatory, nootropic, antiamnesic, antiulcer, antiparasitic, antidiabetic, anticancer, aphrodisiac, antibacterial, anti-in flammatory, antidiarrheal, antioxidant, hepatoprotective, hypocholestrimic, antiu rolithiatic, anti-sebum wound healing effects.
Keywords: Asparagus racemosus ,Asparagaceae, Quercitin, Rutin, Shatavari.

Cite This Article:

Please cite this article in press Akshaya. P et al Therapeutic Application Of Asparagus Racemosus In Depression: A Review., Indo Am. J. P. Sci, 2025; 12(04).

Number of Downloads : 10

References:

1. Prashant Sakharam Bhokardankar, Sandeep Gorakh Mane, Bhupendra Prakash Khairanar, an overview of shatavari (asparagus racemosus) an ayurvedic drug, International Journal of Ayurveda and Pharma Research, 2019;7(7):60-65.
2. Shashi Alok, Sanjay Kumar Jain, Amita Verma, Mayank Kumar, Alok Mahor, Monika Sabharwal, Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review, Asian Pacific Journal of Tropical Disease, 2013; 3(3):242-25.
3. Ramit Singla and Vikas Jaitak. Shatavari (asparagus racemosus wild): a review on its cultivation, morphology, phytochemistry and pharmacological importance. International journal of pharmaceutical sciences and research, 2014;5(3):742-757.
4. Shashikumara, Prathima.C, Mohammed Sibgattullah.Evaluation of Antidepressant Activity of Ethanolic Extract of Alangium Salvifolium Leaves in swiss AlbinoMice. Biomedical & Pharmacology Journal. 2017; 10(1):427-423.
5. Vd. V. M. Gogate, Dravyaguna Vidnyana, Manohar Pimplapure & Co. Publisher, Nagpur, 2nd Edition, 1997, P. 412.
6. Acharya Priyavat Sharma, Dravyaguna Vijnana, 1998, Chaukhamba Bharati Academy, Varanasi, P. 562.
7. Gaitonde BB, Jetmalani MH. Antioxytocic action of saponin isolated from Asparagus racemosus Willd (Shatavari) on uterine muscle. Arch Int Pharmacodyn Ther 1969; 179: 121-129.
8. Joshi JDS. Chemistry of Ayurvedic crude drugs: Part VIII: Shatavari 2. Structure elucidation of bioactive shatavarin I and other glycosides. Indian J Chem Section B Organ Chem 1988; 27(1):12-16.
9. Wiboonpun N, Phuwapraisirisan P, Tip-pyang S. Identification of antioxidant compound from Asparagus racemosus. Phytother Res 2004; 8(9):771-773.
10. Acharya SR, Acharya NS, Bhangale JO, Shah SK, Pandya SS. Antioxidant and hepatoprotective action of Asparagus racemosus Willd. root extracts. Indian J Exp Biol 2012; 50(11):795-801.
11. Yongxia Yin, Xiaofeng Liu, Jinping Liu, Enbo Cai, Yan Zhao. The effect of beta- sistosterol and its derivatives on depression by the modification of 5-HT,DA and GABA-ergic systems in mice. Eur. Neuropsychopharmacol. 2018;8:671-680.
12. Katarzyna Mlyniec. Zinc in the glutamatergic theory of depression. Curr Neuropharmacol. 2015;13(4):505-513.
13. S.M. Aburawi, R.A.AL-Tubuly, E.A. Alghzewi and Z.M. Gorash. Effects of calcium channel blockers on antidepressant action of Alprazolam and Imipramine. Libyan journal of medicine. 2016;2:169-175.
14. Shuai Jin, Lijuan Zhang, Lin Wang. Kaempferol, a potential neuroprotective agent in neurodegenerative diseases. Biomedicine and Pharmacotherapy. 2023;165:115-215.
15. Iandra Holzmann, Luisa Mota da Silva, Jose Afonso Correa da Silva. Antidepressant like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses and the glutamatergic and oxidonitregic pathways. Pharmacology Biochemistry and Behavior. 2015;136:55-63.
16. Suzan A. Khodir. Rutin extert antidepressant effect in a rat model of diabetes. Menoufia Medical Journal. 2023;36(1)106-112.
17. Aogi Song, Zhenghua Wu, Wenjuan Zhao, Wenging Shi. The role and mechanism of hyperoside against depression like behaviour in mice via the NLRP1 Inflammasome. Medical journal. 2022;58(12):1741-1747