Volume : 12, Issue : 04, April – 2025

Title:

FORMULATION AND EVALUATION OF ANTIOXIDANTS CREAM

Authors :

Dnyaneshwari R. Somatkar* , Harishkumar K. Rathod, Swati P. Deshmukh

Abstract :

The present study aimed to formulate and evaluate the antioxidant potential of a topical cream incorporating a blend of natural antioxidants, including vitamin E, . The cream was formulated using a combination of oils and waxes, and its physicochemical properties, such as pH, viscosity, and spreadability, were evaluated. The antioxidant activity of the cream was assessed using in vitro assays, including DPPH radical scavenging and ferric reducing antioxidant power (FRAP). The stability of the cream was evaluated over a period of 60 days. Results showed that the formulated cream exhibited excellent physicochemical properties and significant antioxidant activity, with a DPPH radical scavenging activity of 75.23% and a FRAP value of 435.67 μΜ Fe(II)/g. The cream also demonstrated good stability over the study period. These findings suggest that the formulated antioxidant cream has the potential to provide enhanced skin protection against oxidative stress and damage, making it a valuable addition to skincare regimens.The formulation and evaluation of an antioxidant cream are aimed at developing a topical product that effectively protects the skin from oxidative damage, which is a major cause of premature aging and skin-related disorders. The antioxidant cream was developed using a combination of natural and synthetic antioxidants, including Vitamin C, Vitamin E, and green tea extract. Various formulations were prepared with different concentrations of the active ingredients, and their physical properties, such as color, texture, pH, spreadability, and stability, were evaluated. Additionally, the antioxidant activity was assessed using standard in vitro assays like DPPH Formulations were prepared with different concentrations of the active ingredients, and their physical properties, such as color, texture, pH, spreadability, and stability, were evaluated. Additionally, the antioxidant activity was assessed using standard in vitro assays like DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (Ferric Reducing Antioxidant Power). The final optimized formulation showed promising results in terms of antioxidant activity and stability over time. The cream exhibited good spreadability, desirable texture, and pH suitable for skin application. This study concludes that the developed antioxidant cream has potential as a cosmetic product to protect the skin from oxidative stress and aging, with further clinical evaluation needed for its efficacy and safety in humans
Keywords: Antioxidants, cream formulation, skin protection, vitamin E, green tea extract, grape seed extract

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