Volume : 12, Issue : 04, April – 2025
Title:
EVALUATION OF THE IMPACT OF EXCIPIENTS ON THE BIOAVAILABILITY OF A POORLY SOLUBLE DRUGS
Authors :
Ayan khan*, Ajip A. Rathod, Nandkishor B. Deshmukh, Swati P. Deshmukh
Abstract :
The bioavailability of poorly soluble drugs is a critical concern in pharmaceutical development. One of the primary strategies to enhance drug solubility and, subsequently, bioavailability is through the use of excipients. Excipients, which are inert substances used in drug formulations, can play various roles in improving the dissolution rate and solubility of poorly soluble drugs, thereby enhancing their bioavailability. This abstract evaluates the impact of different types of excipients—such as surfactants, co-solvents, polymers, and lipid-based excipients—on the bioavailability of drugs with low aqueous solubility.
Recent studies have demonstrated that excipients can improve bioavailability by several mechanisms: enhancing drug dissolution, improving drug absorption through modulation of the gastrointestinal environment, and altering the pharmacokinetic profile of drugs.
The oral bioavailability of poorly soluble drugs, often classified as Biopharmaceutical Classification System (BCS) Class II and IV compounds, remains a key obstacle in pharmaceutical development. Inadequate solubility limits dissolution, leading to poor absorption and suboptimal drug efficacy. Excipients, non-active components in drug formulations, play a pivotal role in overcoming these limitations by modifying the drug’s physicochemical properties and promoting more efficient absorption.
Keywords: Excipients, Bioavailability enhancement, Poorly soluble drugs, Solubility enhancement, Pharmaceutical formulation, Drug absorption. Solid dispersion, Permeability enhancement, Pharmacokinetic Drug, solubilisation, Self-emulsifying, drug delivery systems (SEDDS), Bio enhancers.
Cite This Article:
Please cite this article in press Ayan khan et al., Evaluation Of The Impact Of Excipients On The Bioavailability Of A Poorly Soluble Drugs., Indo Am. J. P. Sci, 2025; 12(04).
Number of Downloads : 10
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