Volume : 12, Issue : 04, April – 2025
Title:
PREOPERATIVE MRI AND CLINICAL PREDICTORS OF POSTOPERATIVE SURVIVAL IN TARGETOID PRIMARY LIVER MALIGNANCY AMONG PATIENTS WITH CHRONIC LIVER DISEASE
Authors :
V Natraj Prasad*
Abstract :
The prognosis of patients with targetoid primary liver malignancies (TPLMs), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), remains a clinical challenge, particularly in individuals with chronic liver disease. This study evaluates the predictive value of preoperative magnetic resonance imaging (MRI) features and clinical variables in determining postoperative survival outcomes. We retrospectively analyzed patients undergoing liver resection, correlating MRI findings such as arterial phase hyperenhancement, washout, and capsular retraction with survival data. Clinical parameters, including liver function scores and alpha-fetoprotein levels, were also assessed. Our findings suggest that specific MRI features, when combined with key clinical variables, can serve as reliable prognostic markers to guide surgical decision-making and postoperative management.
Keywords: Targetoid Liver Malignancy, Hepatocellular Carcinoma, Intrahepatic Cholangio carcinoma, MRI Prognostics, Chronic Liver Disease, Postoperative Survival
Cite This Article:
Please cite this article in press V Natraj Prasad et al., Preoperative Mri And Clinical Predictors Of Postoperative Survival In Targetoid Primary Liver Malignancy Among Patients With Chronic Liver Disease.,, Indo Am. J. P. Sci, 2025; 12(04).
Number of Downloads : 10
References:
1. Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391(10127):1301-1314.
2. Zhang Y, Ren J, Huang Y, et al. Intrahepatic cholangiocarcinoma: MRI features and pathologic correlation. Clin Radiol. 2016;71(11):e96-e103.
3. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182-236.
4. Kim YK, Kim CS, Han YM, et al. Detection of HCC with gadoxetic acid-enhanced MRI: correlation with histopathologic findings. Eur Radiol. 2012;22(4):872-880.
5. Besa C, Ward S, Cui Y, et al. Targetoid appearance on MRI: a key feature for diagnosis of primary liver malignancy. Abdom Radiol. 2019;44(4):1443-1452.
6. Rimola J, Forner A, Reig M, et al. Non-invasive diagnosis of HCC: Gadoxetic acid-enhanced MRI versus contrast-enhanced CT. Radiology. 2012;265(1):172-180.
7. Kim BR, Kim DH, Byun JH, et al. Prognostic value of MRI features in intrahepatic cholangiocarcinoma. Eur Radiol. 2019;29(11):5804-5813.
8. Darnell A, Forner A, Rimola J, et al. Liver Imaging Reporting and Data System (LI-RADS) for HCC diagnosis: evaluation in a Western population. Hepatology. 2015;62(6):1826-1835.
9. Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973;60(8):646-649.
10. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33(2):464-470.
11. Trevisani F, D’Intino PE, Morselli-Labate AM, et al. Serum alpha-fetoprotein for diagnosis of HCC. Hepatology. 2001;34(6):1114-1120.
12. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53(3):1020-1022.
13. Park HJ, Jang HY, Kim SY, et al. MRI-based radiomics for survival prediction in liver cancer. Sci Rep. 2020;10(1):1237.
14. Lubner MG, Stabo N, Lubner SJ, et al. CT texture analysis of hepatic tumors: prognostic implications. AJR Am J Roentgenol. 2015;204(5):W505-W512.
15. Lee S, Kim SH, Lee JE, et al. MRI-based prediction of HCC recurrence. J Magn Reson Imaging. 2020;51(3):894-905.
16. Choi SH, Lee SS, Kim SY, et al. Gadoxetic acid-enhanced MRI for HCC diagnosis: imaging-pathology correlation. Liver Cancer. 2020;9(2):169-181.
17. Xu X, Wang Y, Xie H, et al. MRI radiomics predicts survival of HCC patients undergoing resection. Eur Radiol. 2021;31(2):1057-1066.
18. Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2:16018.
19. Sasaki K, Margonis GA, Andreatos N, et al. Prognostic value of preoperative imaging in ICC. J Surg Oncol. 2017;115(8):1016-1025.
20. Renzulli M, Brocchi S, Cucchetti A, et al. Can LI-RADS be used for ICC characterization? Eur Radiol. 2018;28(5):2048-2058.