Volume : 12, Issue : 08, August- 2025
Title:
ROLE OF SUPERDISINTEGRANTS IN IMMEDIATE RELEASE TABLET FORMULATIONS: A COMPREHENSIVE REVIEW
Authors :
Ayesha Anwar, Lubna Nousheen*, Mohammad Shamim Qureshi
Abstract :
Immediate release (IR) tablets are designed to disintegrate and dissolve rapidly, ensuring a fast onset of therapeutic effect. Superdisintegrants, used in small quantities, are essential excipients that accelerate tablet breakup in the presence of aqueous fluids, thereby enhancing dissolution and improving drug bioavailability. This review presents a concise yet comprehensive overview of superdisintegrants, including their types, mechanisms of action, evaluation methods, and roles in IR tablet formulations. Both synthetic and natural variants are discussed, with emphasis on their physicochemical properties, concentration ranges, and compatibility with active pharmaceutical ingredients. Additionally, the paper highlights regulatory considerations, formulation strategies, and advancements such as co-processed and eco-friendly superdisintegrants. By integrating current scientific understanding with practical formulation insights, this work serves as a valuable resource for researchers and formulators seeking to optimize disintegration efficiency and improve patient compliance in oral solid dosage forms.
Keywords: Superdisintegrants, Immediate release, Tablet formulation, Disintegration time.
Cite This Article:
Please cite this article in press Lubna Nousheen et al., Role Of Superdisintegrants In Immediate Release Tablet Formulations: A Comprehensive Review., Indo Am. J. P. Sci, 2025; 12(08).
Number of Downloads : 10
References:
1. Aulton ME. Pharmaceutics: The Science of Dosage Form Design. Churchill Livingstone; 2018.
2. Goel H, Rai P, Rana V. Role of excipients in enhancing the performance of oral solid dosage forms. Drug Dev Ind Pharm. 2022;48(8):397-410.
3. Luniya A, Noman M. Role of superdisintegrants in immediate release formulations. J Sci Res Allied Sci. 2024;10(1):45-58.
4. Mohamed AA. Natural disintegrants in pharmaceutical formulations. J Pharmacol Pharm Res. 2025;7(3):89-102.
5. Garje MSS, Shete AR, Salve MT. Review on formulation and evaluation of voglibose orodispersible tablet. Int J Sci Res. 2025;15(2):112-119.
6. Wankhade A, Joshi U, Biyani K. Fast-acting solutions: A comprehensive review of immediate release oral contraceptive dosage forms. Int J Sci Res Technol. 2025;14(4):230-240.
7. Shinde AB, Raut YB. Review on mouth dissolving tablets. Int J Pharm Res Dev. 2023;15(3):2424-2426.
8. Patil P, Shrivastava SK. Fast disintegrating tablets: An overview. J Pharm Sci Res. 2020;12(3):370-376.
9. Bi YX, Sunada H, Yonezawa Y. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharm Bull. 1999;47(8):1301-1304.
10. Deshmukh VN. Formulation and evaluation of disintegrating tablets using natural and synthetic superdisintegrants. Res J Pharm Tech. 2020;13(2):707-712.
11. Kalia A, Khurana S, Bedi N. Formulation and evaluation of mouth dissolving tablets of oxcarbazepine. Int J Pharm Pharm Sci. 2009;1(1):12-23.
12. Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. 7th ed. Pharmaceutical Press; 2012.
13. Chaudhari SP, Chaudhari SR. A review on superdisintegrants in oral solid dosage form. Asian J Pharm Clin Res. 2021;14(7):18-23.
14. Varma SR, Deshmukh A, Purohit R. Superdisintegrants: An overview. Int J Pharm Res. 2021;13(4):123-130.
15. Patel DM, Patel NM, Patel VF. Studies on formulation and in vitro evaluation of fast dissolving tablets of domperidone. Indian J Pharm Sci. 2008;70(5):640-644.
16. Singh B, Kaur G, Ahuja N. Optimization of disintegration time for fast dissolving tablets using response surface methodology. AAPS PharmSciTech. 2005;6(4):E594-E601.
17. Karmarkar AB, Gonjari ID, Hosmani AH. Optimization of mouth dissolving tablets of meclizine hydrochloride using response surface methodology. Indian J Pharm Sci. 2009;71(5):554-560.
18. Bandari S, Mittapalli RK, Gannu R, Rao YM. Orodispersible tablets: An overview. Asian J Pharm. 2008;2(1):2-11.
19. Kato Y, Wakabayashi S, et al. Development of fast disintegrating tablet using a solid dispersion technique. Eur J Pharm Biopharm. 2022;173:100-110.
20. Fini A, Bergamante V, et al. Fast disintegrating tablets for pediatric use: Formulation considerations. Drug Dev Ind Pharm. 2021;47(3):425-435.
21. Al-Khattawi A, Mohammed AR. Compressed orally disintegrating tablets: Excipients, manufacture and testing. J Drug Deliv Sci Technol. 2014;24(6):609-621.
22. Dobetti L. Fast-melting tablets: Developments and technologies. Pharm Tech. 2001;Suppl:44-50.
23. Habib W, Khankari R, Hontz J. Fast-dissolve drug delivery systems. Crit Rev Ther Drug Carrier Syst. 2000;17(1):61-72.
24. Dixit RP, Puthli SP. Oral strip technology: Overview and future potential. J Control Release. 2009;139(2):94-107.
25. Suresh B, et al. Physicochemical characterization of excipients for solid dosage forms. J Pharm Sci. 2018;107(6):1500-1512.
26. Kumar GP, Raju SA, Shirsand SB. Fast dissolving tablets: An overview. Indian J Pharm Educ Res. 2020;54(4):879-889.
27. Gupta A, Mishra S, Singh S. Role of superdisintegrants in the formulation of oral fast disintegrating tablets: A review. Int J Pharm Sci Res. 2019;10(11):4943-4952.
28. Bhardwaj S, Jain V, Sharma S. Orally disintegrating tablets: A review. Arch Appl Sci Res. 2010;2(2):35-39.
29. Kumar R, Patil MB, Patil SR, Paschapur MS. Formulation evaluation of mouth dissolving tablets of fenofibrate using natural superdisintegrants. Int J PharmTech Res. 2009;1(4):982-987.
30. Badgujar BP, Mundada AS. The technologies used for developing orally disintegrating tablets: A review. Acta Pharm. 2011;61(2):117-139.
31. Thulluru A, Duraivel S, Vardhan S. Formulation and evaluation of fast dissolving tablets: A review. J Drug Deliv Ther. 2021;11(3):141-146.
32. Kamboj S, Rana V. Development of mouth dissolving tablets of amlodipine besylate using novel superdisintegrants. Int J Pharm Sci Res. 2016;7(5):2118-2125.
33. Gohel MC, Patel MM, Amin AF, Agarwal R, Dave R. Formulation design and optimization of mouth dissolving tablets of nimesulide using vacuum drying technique. AAPS PharmSciTech. 2004;5(3):E36.
34. Sharma D. Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders. J Drug Deliv Ther. 2012;2(5):67-73.
35. Heer D, Aggarwal G. Superdisintegrants: An updated review. PharmaTutor. 2014;2(7):35-46.
36. Saha S, Shahiwala AF. Multifunctional co-processed excipients for improved tableting performance. Expert Opin Drug Deliv. 2009;6(2):197-208.
37. Jacob S, Shirwaikar A, Joseph A, Srinivasan KK. Novel co-processed excipients of mannitol and microcrystalline cellulose for preparing fast dissolving tablets. Indian J Pharm Sci. 2007;69(5):633-639.
38. Ahmed IS, Aboul-Ein HA, Shehata T. In vitro and in vivo evaluation of a fast-disintegrating lyophilized dry emulsion tablet containing griseofulvin. Eur J Pharm Sci. 2006;29(1):58-65.
39. Basak SC, Karthikeyan R, Mani S. Formulation and release behaviour of sustained release ambroxol hydrochloride HPMC matrix tablet. Indian J Pharm Sci. 2008;70(5):638-640.
40. Fujioka K, Shibata Y, et al. Development of orally disintegrating tablets containing taste-masked particles: Masking evaluation and clinical taste tests. Int J Pharm. 2020;588:119731.
41. Bala R, Khanna S, Pawar P. Orally dissolving strips: A new approach to oral drug delivery system. Int J Pharm Investig. 2013;3(2):67-76.
42. Bandari S, et al. Current perspectives on disintegrants in solid oral dosage forms: A critical review. Drug Dev Ind Pharm. 2023;49(1):1-13.