Volume : 12, Issue : 08, August- 2025

Title:

DEVELOPMENT AND VALIDATION OF SPECTROSCOPIC METHOD FOR THE QUANTITATIVE ESTIMATION OF FLUVOXAMINE IN BULK AND TABLET DOSAGE FORM

Authors :

Umme Kulsum. *, Naveen Kumar G S

Abstract :

Simple, precise and accurate Area under curve spectroscopic method has been developed and validated for the estimation of Fluvoxamine in bulk and pharmaceutical dosage form. Fluvoxamine exhibits maximum absorbance at 256 nm in Ethanol and Area under curve (AUC) in absorption spectra was measured between the wavelength range 251 to 261nm which obeys Beer’s Law within the concentration range of 5–30 µg/ml. The linearity study was carried out and regression coefficient (R²) was found to be 0.999 and it has showed good linearity, precision during this concentration range. The percentage recovery was found to be 98.8%and 101.0%, while the limits of detection (LOD) and quantification (LOQ) were found to be 0.0922 µg/ml and 0.2796 µg/ml respectively. The method also demonstrated excellent precision, with relative standard deviation (%RSD) values below 2%. All validation parameters—linearity, accuracy, precision, robustness, ruggedness, LOD, and LOQ—were assessed according to ICH guidelines. The developed and validated method can be successfully applied for routine estimation of Fluvoxamine in bulk and pharmaceutical dosage form.
Keywords: Fluvoxamine, Area under curve spectroscopy, Validation, Pharmaceutical formulation.

Cite This Article:

Please cite this article in press Umme Kulsum et al., Development And Validation Of Spectroscopic Method For The Quantitative Estimation Of Fluvoxamine In Bulk And Tablet Dosage Form., Indo Am. J. P. Sci, 2025; 12(08).

Number of Downloads : 10

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