Volume : 12, Issue : 08, August- 2025
Title:
FORMULATION AND EVALUATION OF FLOATING ORAL IN-SITU GELLING SYSTEM OF FAMOTIDINE
Authors :
A Balaraju, Rajkumar Devara
Abstract :
Famotidine was incorporated into an oral in situ gel formulation using sodium alginate, sodium bicarbonate, sodium citrate, and HPMC K4M as gelling agents. Conferring to FT-IR spectroscopy, there was no interaction between the medication and the excipients. All eight of the formulas were aesthetically pleasing, straightforward to work with, and did not gel at room temperature. The ideal in situ gel released an adequate dosage of medication into the stomach by flopping and gelling as intended. Observed water intake ranged from 7.36±0.28 to 29.41±0.24%, while estimated floating lag time ranged from 8.95±0.28 to 56.35±0.34s. F1 and F2 showed floating for 12 hr, whereas all formulations released more than 90% of the drug over the 8 hours.
Keywords: Famotidine, in situ gel, HPMC K4M, Floating system.
Cite This Article:
Please cite this article in press Rajkumar Devara et al ., Formulation And Evaluation Of Floating Oral In-Situ Gelling System Of Famotidine., Indo Am. J. P. Sci, 2025; 12(08).
Number of Downloads : 10
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