Volume : 12, Issue : 08, August- 2025
Title:
DEVELOPMENT AND CHARACTERIZATION OF LIDOCAINE-LOADED TRANSDERMAL GEL
Authors :
Yamjala Ganesh Kumar, Ch.Sai Srujana, A.Chaithanya, A.Rithwika, P.Prashanth Goud, G.Harish, G.Saikumar
Abstract :
The present study was undertaken to formulate and evaluate the transdermal gel of Lidocaine. Lidocaine is a drug of choice used in the treatment of hypertension. The transdermal gel has gained more and more importance because gel-based formulations are better percutaneously absorbed than creams and ointment bases. Therefore, the transdermal gel of Olmesartan was prepared using different polymers such as Carbopol 934, containing a permeation enhancer, PEG 400 at different proportions. The study encompasses compatibility studies using FTIR spectra, drug content, viscosity, spreadability, Extrudability, and pH determination. Further, the optimized formulation F2 was evaluated by in vitro diffusion study. The preliminary compatibility studies conducted revealed that there was no interaction between Lidocaine with excipients. In vitro drug release study was carried out with a Franz diffusion cell using a cellophane membrane in pH 7.4 phosphate buffer as the diffusion medium. Formulation batch F2 containing Carbopol 934P and PEG 400 permeation enhancer showed 94.69%, Stability studies conducted under accelerated conditions were shown satisfactory results. It was concluded that Carbopol gel 934 containing Olmesartan showed good spreadability, Extrudability, stability and pH. So, the transdermal gel had wider prospect for transdermal preparations.
Keywords: Lidocaine Carbopol 934, Extrudability, spreadability in vitro diffusion studies.
Cite This Article:
Please cite this article in press Y. Ganesh Kumar et al., Development And Characterization Of Lidocaine-Loaded Transdermal Gel., Indo Am. J. P. Sci, 2025; 12(08).
Number of Downloads : 10
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