Volume : 12, Issue : 08, August- 2025
Title:
INDOLE-BASED ALKALOIDS HAVE WIDE RANGE OF BIOLOGICAL ACTIVITIES, INCLUDING ANTITUMOR, ANTI-INFLAMMATORY, ANTIMICROBIAL, AND ANTIVIRAL ACTIVITIES
Authors :
Musarrath Mubeen*,Rangam Chariitha, K.Keerthika, Dr.T.Mangilal
Abstract :
Indole alkaloids which are abundance in nature are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert the anticancer activity via various ant proliferative mechanisms, and some of them such as Vinblastine and Vincristine have already used in clinic or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship and mechanisms of action covering the articles published from 2015 to 2020.
Key Words: Indole alkaloids, anticancer activity, ant proliferative mechanisms, clinical evaluations.
Cite This Article:
Please cite this article in press Muarrath Mubeen et al., Indole-Based Alkaloids Have Wide Range Of Biological Activities, Including Antitumor, Anti-Inflammatory, Antimicrobial, And Antiviral Activities., Indo Am. J. P. Sci, 2025; 12(08).
Number of Downloads : 10
References:
1,Hiromitsu Takayama (2004). “Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa”. Chemical and Pharmaceutical Bulletin. 52 (8): 916–928. doi:10.1248/cpb.52.916. PMID 15304982.
2.Kulshreshtha, Ankita; Saxena, Jyoti (2019). “Alkaloids and Non Alkaloids of Tabernaemontana divaricata” (PDF). International Journal of Research and Review. 6 (8): 517–524.
3.Fricke, Janis; Blei, Felix; Hoffmeister, Dirk (2017-09-25). “Enzymatic Synthesis of Psilocybin”. Angewandte Chemie International Edition. 56 (40): 12352– 12355. doi:10.1002/anie.201705489. PMID 28763571.
4.Casapullo A., Bifulco G., Bruno I., Riccio R. New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei. J. Nat. Prod. 2000;63:447–451. [PubMed] [Google Scholar]
5.El-Sayed M., Verpoorte R. Catharanthus terpenoid indole alkaloids: biosynthesis and regulation. Phytochem. Rev. 2007;6:277–305. [Google Scholar]
6.Gul W., Hamann M.T. Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases. Life Sci. 2005;78:442–453. [PMC free article] [PubMed] [Google Scholar]
7.Kam T., Choo Y. Bisindole alkaloids. Alkaloids: Chem. Biol. 2006;63:181– 337. [PubMed] [Google Scholar]
8.Baeyer A. Ueber die Reduction aromatischer Verbindungen mittelst Zinkstaub. Justus Liebigs Ann. Der Chem. 1866;140:295–296. doi: 10.1002/jlac.18661400306. – DOI.
9.Wang W., Cheng M.-H., Wang X.-H. Monoterpenoid indole alkaloids from Alstonia rupestris with cytotoxic, anti-inflammatory and antifungal activities. Molecules. 2013;18:7309–7322. doi: 10.3390/molecules18067309. – DOI – PMC – PubMed
10.Kochanowska-Karamyan, A. J., and Hamann, M. T. (2010). Marine indole alkaloids: potential new drug leads for the control of depression and anxiety. Chem. Rev. 110, 4489– 4497. doi: 10.1021/cr900211p.
11.de Sa, A., Fernando, R., Barreiro, E. J., Fraga, M., and Alberto, C. (2009). From nature to drug discovery: the indole scaffold as a ‘privileged structure’. Mini Rev. Med. Chem. 9, 782– 793. doi: 10.2174/138955709788452649.
12.Otero N., Mandado M., Mosquera R.A. Nucleophilicity of Indole Derivatives: Activating and Deactivating Effects Based on Proton Affinities and Electron Density Properties. J. Phys. Chem. A. 2007;111:5557–5562. doi: 10.1021/jp0708953. – DOI – PubMed
13.Dewick P.M. Essentials of Organic Chemistry: For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry. John Wiley & Sons; Hoboken, NJ, USA: 2006.
14.Zhang L., Zhang C.-J., Zhang D.-B., Wen J., Zhao X.-W., Li Y., Gao K. An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris. Tetrahedron Lett. 2014;55:1815–1817. doi: 10.1016/j.tetlet.2014.01.122. – DOI
15.Fadaeinasab M., Basiri A., Kia Y., Karimian H., Ali H.M., Murugaiyah V. New indole alkaloids from the bark of Rauvolfia reflexa and their cholinesterase inhibitory activity. Cell. Physiol. Biochem. 2015;37:1997–2011. doi: 10.1159/000438560. – DOI – PubMed
16.Andrade M.T., Lima J.A., Pinto A.C., Rezende C.M., Carvalho M.P., Epifanio R.A. Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme. Bioorganic Med. Chem. 2005;13:4092–4095. doi: 10.1016/j.bmc.2005.03.045. – DOI – PubMed
17.Zhan Z.-J., Yu Q., Wang Z.-L., Shan W.-G. Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities. Bioorganic Med. Chem. Lett. 2010;20:6185–6187. doi: 10.1016/j.bmcl.2010.08.123. – DOI – PubMed
18.Diniz M.F.M., Da Silva B.A., Mukherjee R. Spasmolytic actions of the new indole alkaloid trinervine from Strychnos trinervis root. Phytomedicine. 1994;1:205–207. doi: 10.1016/S0944-7113(11)80066-8. – DOI – PubMed
30.Cheng G.-G., Li D., Hou B., Li X.-N., Liu L., Chen Y.-Y., Lunga P.-K., Khan A., Liu Y.-P., Zuo Z.- L., et al. Melokhanines A–J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus. J. Nat. Prod. 2016;79:2158–2166. doi: 10.1021/acs.jnatprod.6b00011. – DOI – PubMed.




