Volume : 12, Issue : 08, August- 2025
Title:
SMART POLYMER FOR NOVEL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW
Authors :
Prashant Purohit* and Dishant Jain
Abstract :
Novel drug delivery system utilizing smart polymer to get significant and attracting changes in the targeting of drugs, increasing the bioavailability of drugs, enhancement patient compliance and gene therapy. The scientific community tries to mimic nature in the way that living organisms adopt their behavior as a function of environmental conditions to improve survival. In this sense, smart polymers offer materials that respond to numerous stimuli (temperature, pH, electric and magnetic fields, light intensity, biological molecules, etc.), and scientists must devise the best way to apply them in all research areas. Smart polymers are representing promising means for targeted drug delivery, enhanced drug delivery, gene therapy, actuator stimuli and protein folders. Smart polymers are very promising applicants in drug delivery, tissue engineering, cell culture, gene carriers, textile engineering, oil recovery, radioactive wastage and protein purification. The study is focused on the entire features of smart polymers and their most recent and relevant applications.
KEYWORDS: Smart polymer, Novel drug delivery system, Stimuli, Gene therapy.
Cite This Article:
Please cite this article in press Prashant Purohit et al., Smart Polymer For Novel Drug Delivery System: An Updated Review., Indo Am. J. P. Sci, 2025; 12(08).
Number of Downloads : 10
References:
1 Davis SS, Illum L. Long circulating microparticulate drug carriers. Int J Pharm, 1998; 176:1-8.
2 Jeong B, Gutowska A. Lessons from nature: stimuli responsive polymers and their biomedical applications. Trends Biotechnol, 2002; 20:305-11.
3 Hoffman AS, Stayton PS, Bulmus V, Chen G, Jinping C, Chueng C, et al. Really smart bioconjugates of smart polymers and receptor proteins. J Biomed Mater Res, 2000; 52:577-86.
4 Prashant Purohit and Himisha Gaur, Lipid Based Nano Particles in Cancer Therapy, Indo American Journal of Pharmaceutical Research, 4(2023).225-29
5 Galaev IYu, Mattiasson B. ‘Smart’ polymers and what they could do in biotechnology and medicine. Trends Biotechnol, 2000; 17:335-40.
6 Kikuchi A, Okano T. Intelligent thermoresponsive polymeric stationary phases for aqueous chromatography of biological compounds. Prog Polym Sci, 2002; 27:1165-93.
7 Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev, 2001; 53:321-39.
8 Prashant Purohit, Mahesh Kumar Kataria, Phytochemicals screening, antioxidant and antimicrobial activity of carica papaya leaf extracts. Int j curr pharm sci. 2024 may 15; 16(3):95-98.
9 Prashant Purohit, Mahesh Kumar Kataria, Formulation and Evaluation of Polyherbal Ointment Using Carica Papaya and Leptadenia Pyrotechnica, International Journal of Current Pharmaceutical Review and Research, 2024; 16(5); 22-27
10 Okano T. Molecular design of temperature-responsive polymers as intelligent materials. In: Dusek K, editor. Responsive gels: volume transitions, vol. II. Berlin: Springer; 1993. pp. 180-97.
11 Twaites BR, Alarcon CH, Cunliffe D, Lavigne M, Pennadam S, Smith JR, et al. Thermo and pH responsive polymers as gene delivery vectors: effect of polymer architecture on DNA complexation in vitro. J Control Release, 2004; 97:551-66.
12 Lomadze N, Schneider H-J. Ternary complex formation inducing large expansions of chemomechanical polymers by metal chelators, aminoacids and peptides as effectors. Tetrahedron Lett, 2005; 46:751-4.
13 Kabanov VA. Physicochemical basis and the prospects of using soluble interpolyelectrolyte complex. Polym Sci, 1994; 36:143-56.
14 Prashant Purohit, Kruti Joshi and Yoshita Aggarwal, development and validation of RP-HPLC method for estimation of Naftopidil as API and in tablet dosage form, world journal of pharmacy and pharmaceutical sciences, volume 5, issue 10, 511-526
15 Prashant Purohit and Harendra Singh Rathore, ISABGOL: A HERBAL REMEDY, World Journal of Pharmaceutical Research, Volume 8, Issue 7, 579-585.
16 Prashant Purohit and Sahil, A review on wound healing activity of medicinal plants, international journal of pharmaceutics & drug analysis, VOL.6, ISSUE 7, 2018; 545 – 547
17 Prashant Purohit , Priyanka Mishra and Renu Bhati, Gestational Diabetes Mellitus: An Updated Review, RUHS Journal of Health Sciences, Volume 4 Number 4, October-December 2019, 223-26
18 Prashant Purohit and Priyanka Mishra, Phytosomes as innovative delivery systems for phytochemicals: An updated review, International Journal of Pharmaceutical Research and Development 2025; 7(1): 16-25,
19 Prashant Purohit and Mayank Goyal, Artificial Intelligence in Pharmaceutical Sector: An Overview of Innovation, Indo American Journal of Pharmaceutical Research.2024:14(03),