Volume : 12, Issue : 12, December- 2025

Title:

FORMULATION AND EVALUATION OF EMPAGLIFLOZIN-LOADED ETHOSOMES

Authors :

Sahareyar Raj Laskar. RajKumar Devara

Abstract :

The goal of personalised care plans for people with type 2 diabetes is to enhance their quality of life. The major objective of this study was to create a new vesicular drug delivery system (ethosomal gel) that incorporates empagliflozin for the treatment of diabetes. The gel evaluated vesicle size, PDI, Zeta Potential, % Entrapment efficiency, and vesicular shape.According to SEM examination, optimised ethosomal gel was found to have unilamellar vesicles with a size range of a few microns to a few nanometres. DSC and FT-IR studies revealed that empagliflozin was successfully integrated into ethosomes, indicating that it was in an amorphous state within ethosomes.

Cite This Article:

Please cite this article in press Rajkumar Devara et al., Formulation And Evaluation Of Empagliflozin-Loaded Ethosomes , Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

References:

1. Cal, Krzysztof. Skin disposition of menthol after its application in the presence of drug substances. Biopharm. Drug Dispose. 2008; 29:449-454.
2. Cevc, Gregor. Lipid vesicles and other colloids as drug carriers on the skin. Adv. Drug Deliv. Rev. 2004; 56:675-711.
3. Cevc G, Schatzlein A, Blume G. Transdermal drug carriers: Basic properties, optimization and transfer efficiency in case of epicutaneously applied peptides. J.Control. Rel. 1995; 36:3-16.
4. Verma DD, Fahr A. Synergistic Penetration Enhancement Effect of Ethanol and Phospholipids on The Topical Delivery of Cyclosporin A. J. Control. Release.2004; 97:55-66.
5. Tyagi LK, Kumar S, Maurya SS, et al. Ethosomes: Novel Vesicular Carrier for Enhanced Transdermal Drug Delivery System. Bull. Pharm. Res. 2013; 3: 6-13.
6. Touitou E, Dayan N, Bergelson L, et al. Ethosomes—novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J. Control. Release. 2000; 65:403-418.
7. Ainbinder D, Touitou E. Testosterone ethosomes for enhanced transdermal delivery. Drug deliv. 2005; 12:297-303.
8. Barry B W. Novel mechanisms and devices to enable successful transdermal drug delivery, Eur.J.Pharm. Sci. 2001; 14:101-114.
9. Muller.C.C. “Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration”. European Journal of Pharmaceutics and Biopharmaceutics. 2004; 58(2): 343-356.
10. Arunachalam A, karthikeyan M, Vinay Kumar D. “Transdermal Drug Delivery System: A Review”. Current Pharma Research. 2010; 1(1); 70-81.
11. Shahwal V, Samnani A, Dubey B, Bhowmick M. “Ethosomes: An Overview”. International Journal of Biomedical and Advance Research. 2011;2: 161-168.
12. Leigh C. “Anti-aging products for skin, hair and nails: how vitamins, antioxidants and fruit acids keep people looking young”. Issue of Nutrition Science News 2000. Indian Pharmacopoeia. Controller of Publiation; volume-1:281.
13. Touitou E, Godin B and Weiss C. Enhanced delivery of drug into and across the skin by ethosomal carrier. Drug Develop Res 2000; 50:406-415.
14. Paolino D, Lucania G, Mardente D, et al. Ethosome for skin delivery of ammonium glycyrrhizinate: In vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Cont Rel 2005; 106:99-110.
15. Nandy BC, Gupta RN, Rai VK, et al. Transdermal Iontophoresis delivery of Atenolol in combination with penetration enhancers: optimization and evaluation on solution and gels. Int.J. Pharm. Sci. Drug Res. 2009; 1:91-9.
16. Rao Y, Zheng F, Zhang X, et al. In vitro percutaneous permeation and skin accumulation of finasteride using vesicular Ethosomal carrier. AAPS PharmSciTech.2008; 9:8605.
17. Nguyen PL, Bowstra JA. Vesicles as a tool for transdermal and dermal delivery. Drug Disc Tec 2005; 2:67-74.
18. Jepps OG, Dancik Y, Anissimov YG, et al. Modelling the human skin barrier–towards a better understanding of dermal absorption. Adv Drug Deliv Rev 2013; 65: 152-168.
19. Patel S. Ethosomes: A promising tool for transdermal delivery of drug. Pharmainfo.net, 2007; 5.
20. Koskela RV, Kirjavainen M, Monkkonen J, Dritti A, Keisvaara J. “Enhancement of percutaneous absorption of naproxen by phospholipids”. International journal of pharmaceutics. 1998; 175:225- 230.
21. Matteucci M, Casella M, Bedoni M, Donetti E, Fanetti M, Angelis F.D.F, Gramatica F, Fabrizio E.D. “A compact and disposable transdermal drug delivery system”. Microelectronic Engineering 2008; 85,1066-1073.
22. Vishwakarma S.K, Niranjan S.K, Irchhaiya R, Kumar N, Akhtar A. “A Novel transdermal drug delivery system”. International Journal of research of pharmacy. 2012; 3(8),39-44 14