Volume : 12, Issue : 12, December- 2025

Title:

REVIEW ON “NATURAL POLYMER–BASED GELLING SYSTEMS FOR DICLOFENAC SODIUM: ADVANCES IN XANTHAN GUM FORMULATIONS

Authors :

Mr. Abhijit V. Sarode, Asso. Prof.Irshad Ahmad, Dr. Mudabbirul Haque

Abstract :

Topical gels have become an important approach for delivering anti-inflammatory drugs directly to affected tissues while minimizing systemic side effects. Diclofenac sodium is one of the most widely used NSAIDs for dermal therapy because it can provide rapid pain relief and localized action. In recent years, natural polymers have gained attention as safer, biodegradable, and more skin-friendly alternatives to synthetic gelling agents. Among these materials, xanthan gum stands out due to its strong viscosity-building capacity, shear-thinning behavior, stability, and excellent compatibility with hydrophilic drug systems. This review highlights recent advances in natural polymer–based gels for diclofenac sodium, with emphasis on formulation methods, rheological behavior, drug release mechanisms, permeation characteristics, and stability considerations. The article also summarizes comparative findings between natural and synthetic polymers, demonstrating the potential of xanthan gum to improve therapeutic performance in topical gel formulations.
Keywords: Diclofenac sodium; xanthan gum; natural polymers; topical gel; dermal delivery; rheology; drug release; anti-inflammatory therapy.

Cite This Article:

Please cite this article in press Abhijit V. Sarode et al., Review On “Natural Polymer–Based Gelling Systems For Diclofenac Sodium: Advances In Xanthan Gum Formulations’’, Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

References:

1. Abdel-Rahman, S.I., & Ahmed, S.M. (2019). Formulation and evaluation of diclofenac sodium topical gels using natural polymers. International Journal of Pharmaceutics and Pharmaceutical Sciences, 11(4), 22–30.
2. Ahmed, T., & Shahzad, Y. (2020). Xanthan gum-based hydrogels for controlled drug delivery: A comprehensive review. Carbohydrate Polymers, 230, 115567.
3. Akhtar, N., & Khan, B.A. (2018). Effect of polymer type on physical characteristics of topical gels. Journal of Pharmaceutical Innovation, 13(2), 75–83.
4. Ali, A., & Khar, R.K. (2023). Rheological and release behavior of natural polymer gels containing diclofenac. Journal of Drug Delivery Science and Technology, 80, 104154.
5. Anzar, N., & Ansari, S.H. (2021). Natural polymers in topical drug delivery: Applications and advances. Phytotherapy Research, 35(9), 4990–5002.
6. Basha, M., et al. (2013). Preparation and evaluation of diclofenac sodium gel using polymer combinations. Saudi Pharmaceutical Journal, 21(2), 179–186.
7. Bayomi, M.A. (2016). Characterization of xanthan gum gels for pharmaceutical use. AAPS PharmSciTech, 17(4), 782–789.
8. Bhattacharya, S., & Mandal, U.K. (2022). Controlled release mechanisms in hydrophilic gels. Drug Development and Industrial Pharmacy, 48(7), 1110–1121.
9. Chakraborty, S., & Nath, L.K. (2019). Natural polysaccharides for topical pharmaceutical formulations. Journal of Applied Polymer Science, 136(12), 47219.
10. Das, S.K., & Sen, A.K. (2021). Evaluation of topical anti-inflammatory gels: A technical update. Indian Journal of Pharmaceutical Sciences, 83(1), 12–25.
11. Deshmukh, M., & Pawar, S. (2019). Development of herbal and synthetic polymer-based gels. Journal of Cosmetic Dermatology, 18(6), 1714–1722.
12. El-Borady, O.M., et al. (2020). Impact of xanthan gum concentration on gel viscosity and drug release. Polymers for Advanced Technologies, 31(10), 2281–2290.
13. El-Mahrouk, G.M. (2017). Comparative analysis of carbopol and natural polymer gels. International Journal of PharmTech Research, 10(2), 146–154.
14. Fathy, M., & Elkashlan, M. (2014). Formulation variables affecting release of diclofenac from gels. International Journal of Drug Development and Research, 6(3), 22–30.
15. Goyal, R., & Mehta, A. (2018). A review on natural polymers in topical delivery. Asian Journal of Pharmaceutical Research, 8(3), 151–159.
16. Gupta, R., & Singh, R. (2020). Characterization and rheology of xanthan gum-based semisolids. Colloids and Surfaces B: Biointerfaces, 196, 111313.
17. Harish, N.M., & Prabhakar, B. (2011). Design of topical anti-inflammatory gels using novel polymers. Indian Drugs, 48(6), 45–52.
18. Jain, S., & Kumar, D. (2019). Physicochemical evaluation of NSAID gels. Journal of Applied Pharmaceutical Science, 9(7), 112–120.
19. Jena, S.K., & Singh, S. (2017). Stability studies of polymer-based topical gels. Journal of Chemical and Pharmaceutical Research, 9(4), 115–123.
20. Kalia, Y.N., & Guy, R.H. (2019). Dermal absorption enhancement techniques. Advanced Drug Delivery Reviews, 146, 70–88.
21. Kanwar, R., & Kaur, H. (2021). Natural biopolymers for pharmaceutical gels: A review. Journal of Bioactive Materials, 6(4), 410–420.
22. Khan, M.S., & Raza, K. (2020). Biocompatible gel matrices for topical delivery. Biomedical Materials, 15(6), 065018.
23. Kothari, A., & Jain, V. (2024). Recent progress in natural gel formulations for NSAIDs. Journal of Drug Delivery and Therapeutics, 14(1), 98–110.
24. Kumar, L., & Verma, R. (2023). Evaluation techniques for topical gels: An updated review. Critical Reviews in Therapeutic Drug Carrier Systems, 40(2), 145–170.
25. Lee, C.M., & Kim, J. (2018). Advances in rheological characterization of biopolymer gels. Food Hydrocolloids, 75, 1–12.
26. Mahajan, A., & Kaur, T. (2021). Development of sustained release topical gels using polysaccharides. European Journal of Pharmaceutical Sciences, 163, 105874.
27. Malik, R., & Singh, P. (2022). Comparative performance of natural and synthetic polymers in dermal gels. Journal of Polymer Research, 29(1), 32.
28. Mishra, B., & Patel, M. (2013). Development and evaluation of diclofenac transdermal systems. Acta Pharmaceutica, 63(1), 79–90.
29. Mohapatra, S., & Sahoo, S. (2021). Polymer–drug interaction studies in topical formulations. Journal of Molecular Liquids, 333, 115970.
30. Patel, R.P., & Patel, M.M. (2017). Formulation requirements for dermal gels. International Journal of Pharmaceutical Sciences Review and Research, 42(2), 74–82.