Volume : 12, Issue : 12, December- 2025
Title:
A REVIEW ON THE PHYTOCHEMICAL, PHARMACOLOGICAL, AND NEUROPROTECTIVE PROFILE OF CONVOLVULUS PROSTRATUS (SHANKHPUSHPI)
Authors :
Mrs.Nerella Indira Rani , Dr. B. Siva Jyothi, B.Abhikya Anunai, A. Sri Lalitha Sahitya
Abstract :
The current review discusses in detail the traditional uses, phytochemical composition, pharmacological activities, structure-activity relationships, extraction techniques, and formulation development of Convolvulus prostratus, commonly known as Shankhpushpi. The plant contains a wide variety of bioactive compounds, including alkaloids like convolamine and convolvine, flavonoids such as kaempferol and scopoletin, sterols like β-sitosterol, and fatty acids, carbohydrates, and proteins. The collective contribution of these constituents to the plant has been well-documented regarding its nootropic, neuroprotective, anxiolytic, antioxidant, and hypolipidemic activities.
The review describes in detail the mechanisms underlying these actions, especially focusing on pathways related to neurodegenerative diseases: the inhibition of β-amyloid aggregation, modulation of tau protein phosphorylation, enhancement of cholinergic transmission, and activation of endogenous antioxidant enzymes. Such mechanisms support the growing scientific interest in C. prostratus as a potential therapeutic agent for conditions like Alzheimer’s disease and cognitive decline. The paper further elaborates on the structure-activity relationships of major phytoconstituents, outlining commonly used extraction approaches such as successive solvent extraction and methanolic maceration. Advances in formulation development, aimed at enhancing bioavailability and standardization, are reviewed. The present review compiles traditional knowledge and contemporary scientific findings and emphasizes the therapeutic potential of Shankhpushpi and encourages future research efforts targeting standardized preparations with rigorous clinical validation.
Keywords:- Shankhpushpi, Memory enhancer, Neuro degenerative, Natural Products, Convolvulus prostrates.
Cite This Article:
Please cite this article in press Nerella Indira Rani et al., A Review On The Phytochemical, Pharmacological, And Neuroprotective Profile Of Convolvulus Prostratus (Shankhpushpi), Indo Am. J. P. Sci, 2025; 12(12).
Number of Downloads : 10
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