Volume : 12, Issue : 12, December- 2025

Title:

INFLUENCE OF CASTING SOLVENT IN DESIGN AND DEVELOPMENT OF VERAPAMIL HYDROCHLORIDE MATRIX TABLETS

Authors :

I. Sri Krishnanjaneyulu, B.Sannihitha, B .Sai Mouni, D .Akshita

Abstract :

The present study was conducted to formulate and evaluate sustained-release matrix tablets of Verapamil hydrochloride using Rosin and Xanthan gum, and to compare the results with a marketed formulation. The effects of three granulating fluids—acetone, isopropyl alcohol, and dichloromethane—and two polymers, Rosin and Xanthan gum, on the drug-release rate were investigated with the aim of developing a controlled-release dosage form for Verapamil hydrochloride. Based on the release profiles, the polymer ratios were ranked in the following order: 1:0 > 0.75:0.25 > 0.6:0.4 > 0.5:0.5 > 0:1 (Rosin:Xanthan gum). The granulating fluids were ranked as dichloromethane > isopropyl alcohol > acetone in terms of their ability to modulate drug release. Dissolution studies indicated that the formulations followed zero-order kinetics, and the drug-release mechanism was best described by the Peppas model. The release exponent values (n > 0.5) suggested that drug release was predominantly governed by non-Fickian diffusion. Overall, the findings demonstrate that the release rate of Verapamil hydrochloride from matrix tablets can be effectively controlled by selecting appropriate granulating fluids, polymers, and polymer concentrations. The desired sustained-release profile was achieved using acetone as the granulating fluid and a Rosin:Xanthan gum ratio of 0.75:0.25.
Key Words : Rosin , Xantham gum, granulating fluids, matrix tables

Cite This Article:

Please cite this article in press I. Krishnanjanaeylu et al., Influence Of Casting Solvent In Design And Development Of Verapamil Hydrochloride Matrix Tablets, Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

References:

1. Aachal Kolhe, Akshda Chauhan, Aishwarya Dongre. To Study the effect of Cross linking of Sodium Alginate on the Rate of Drug Release. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):127-2.
2. Sanjay D, Bhaskar M, Sankha C, Das MK, Samrendu S, Ganguly S, Kakali D, Mridula M. Polymers derived from xanthomonas compesteries and retardant materials for the formulation of sustained release floating matrix tablet of atenolol. Int J BioL Macromol 2014; 651:345-56..
3.Thapa P., Lee A.R., Choi D.H., Jeong S.H. Effects of moisture content and compression pressure of various deforming granules on the physical properties of tablets. Powder Technol. 2017;310:92–102. .
4.Kuwata A, Ishikawa A, Ono T, Yonemochi E. Granulation Methods and the Mechanisms for Improving Hardness of Loxoprofen Sodium Hydrate-Containing Tablets. Pharmaceutics. 2025;17(4):445-455.
5. Hirai N., Takatani-Nakase T., Takahashi K. Preparation and Evaluation of Ibuprofen Solid Dispersion Tablets with Improved Dissolution and Less Sticking Using Porous Calcium Silicate. J. Pharm. Pharmacol. 2018;6:1–8..
6.Arndt O.-R., Baggio R., Adam A.K., Harting J., Franceschinis E., Kleinebudde P. Impact of Different Dry and Wet Granulation Techniques on Granule and Tablet Properties: A Comparative Study. J. Pharm. Sci. 2018;107:3143–3152. .
7.Maharjan R., Lee J.C., Kim N.A., Jeong S.H. Preparation of seeded granules to improve mechanical properties and various drug loading for pharmaceutical application. Powder Technol. 2021;392:650–660.
8. Waghmare RS. Dry Granulation by Slugging Method for Sustained Release of Model Drug. International Journal of Pharmacy and Pharmacutical Research. 2020;17(3):29-77.