Volume : 12, Issue : 12, December- 2025

Title:

STEM CELL THERAPY IN CARDIOVASCULAR SYSTEM

Authors :

Pradhum Jivan Chavhan, Ashwini Dipak Uke

Abstract :

Stem cell therapy has emerged as a promising strategy for repairing damaged cardiac tissue and improving outcomes in cardiovascular disease, a leading cause of morbidity and mortality worldwide. Various stem cell types including mesenchymal stem cells, induced pluripotent stem cells, and cardiac progenitor cells have demonstrated potential to enhance myocardial regeneration, promote angiogenesis, and modulate inflammatory responses following ischemic injury. Despite encouraging preclinical results, clinical translation remains limited by challenges such as low cell retention, variable therapeutic efficacy, immune compatibility, and concerns regarding arrhythmogenic or tumorigenic risks. Advances in biomaterials, gene editing, and extracellular vesicle–based therapies are helping to overcome these barriers and refine delivery methods. Continued interdisciplinary research is essential to optimize safety, durability of benefits, and large-scale applicability. Overall, stem cell–based interventions represent a rapidly evolving avenue with the potential to transform the management of cardiovascular diseases.
Keywords: Stem cell therapy; Cardiovascular regeneration; Myocardial repair; Mesenchymal stem cells; Induced pluripotent stem cells; Cardiac progenitor cells; Angiogenesis; Ischemic heart disease; Cell-based therapy; Regenerative medicine.

Cite This Article:

Please cite this article in press Pradhum Jivan Chavhan et al., Stem Cell Therapy In Cardiovascular System, Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

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