Volume : 12, Issue : 12, December- 2025

Title:

REVIEW ON FORMULATION AND EVALUATION OF HERBAL TABLET CONTAINING OSCIMUM SANCTUM (TULSI)

Authors :

Nutan Vijay Rathod , Shruti A.Wankhade.

Abstract :

Tulsi is a Sanskrit word which means “matchless one”. Each part of the plant i.e. stem, leaves, root, flower, seed or whole plant is known formedicinal properties, therefor ocimum sanctum is regarded as “QUEEN OF HERB”. Several medicinal properties have been attributed to the Tulsi plant not only in Ayurveda and Siddha but also in Greek, Roman and Unani systems of medicine. Herbs used within Ayurveda, Tulsi (Ocimum sanctum Linn) is most excellent, has been proved for its beneficial effect. Ayurveda is a science of life from the ancient time, Ayurvedic formulations are safe and effective but adulteration of lower cost material in it reduces the quality of the drug, hence the standardization of herbal drugs is necessary. Tulsi tablets are an Ayurvedic formulation used for cold and cough. Standardization of Tulsi tablet was performed for determination of its standard parameters as per monograph to maintain the safety, uniformity and quality production of the product.. Many medicinal properties have been attributed to Ocimum sanctum L.
The leaves, flowers, stems, roots, seeds, etc. of the plant are known to have therapeutic potential and are used by traditional medicine practitioners, as expectorant, analgesic, anticancer, antiasthmatic, antiemetic ,diaphoretic, antidiabetic, antifertility. The major importance of the study lies in the cost- effective treatment of contaminated well water samples in various rural households. This can be achieved by using a natural herbal essence of Ocimum sanctum. The treatment is simple, environment-friendly and accessible for all and the constituent present in herbs have no side effects to human compared to chemical treatment. These findings will support the traditional knowledge of local users and it will be a scientific, validation for the use of these plants for antibacterial activity.
Keywords: Ocimum Sanctum, Tulsi Tablet ,standardisation.

Cite This Article:

Please cite this article in press Nutan Vijay Rathod et al., Review On Formulation And Evaluation Of Herbal Tablet Containing Oscimum Sanctum (Tulsi), Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

References:

1. World Health Organisation. Department of Chronic Diseases and Health Promotion. Preventing Chronic Diseases: A Vital Investment: WHO Global Report. Geneva: World Health Organization; 2005. p18.
2. Bast F, Rani P, Meena D. Chloroplast DNA phylogeography of holy basil (Ocimum tenuiflorum) in Indian subcontinent. Scientific World Journal 2014; 2014:847‑482.
3. Singh N, Hoette Y, Miller R. Tulsi: The Mother Medicine of Nature. 2nd ed.Lucknow: International Institute of Herbal Medicine; 2010. p. 28‑47.
4. Mahajan N, Rawal S, Verma M, Poddar M, Alok S.A phytopharmacological overview on Ocimum species with special emphasis on Ocimum sanctum. Biomed Prev Nutr 2013; 3:185- 92.
5. Mohan L, Amberkar MV, Kumari M. Ocimum sanctum linn. (TULSI)-an overview. Int J Pharm Sci Rev Res 2011;7: 51‑3.
6. Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacogn Rev 2010;4:95- 105.
7. Mondal S, Mirdha BR, Mahapatra SC. The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J PhysiolPharmacol 2009; 53:291-306.
8. Wangcharoen W, Morasuk W. Antioxidant capacity and phenolic content of holy basil.Songklanakarin J Sci Technol 2007; 29:1407‑15.
9. Panda VS, Naik SR. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Altern Med Rev 2009; 14:161‑71.
10. Shivananjappa M, Joshi M. Aqueous extract of tulsi (Ocimum sanctum) enhances endogenous antioxidant defenses of human hepatoma cell line (HepG2). J Herbs Spices Med Plants 2012; 18:331-48.
(a) Manikandan P, Murugan RS, Abbas H, Abraham SK, Nagini S. Ocimum sanctum Linn. (Holy Basil) ethanolic leaf extract protects against 7,12‑dimethylbenz anthracene-induced genotoxicity, oxidative stress, andimbalance in xenobiotic-metabolizing enzymes. J MedFood 2007; 10:495‑502.
11. Siddique YH, Ara G, Beg T, Afzal M. Anti-genotoxic effect of Ocimum sanctumL. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells. Acta Biol Hung 2007; 58:397‑409.
12. Jha AK, Jha M, Kaur J. Ethanolic extracts of Ocimum sanctum, Azadirachta indica And Withania somnifera cause apoptosisin SiHa cells. Res J Pharm Biol Chem 2012; 3:557‑62.
13. Manikandan P, Vidjaya Letchoumy P, Prathiba D, Nagini S.
14. Maxia A, Frau MA, Falconieri D, Karchuli MS, Kasture S. Essential oil of myrtuscommunis inhibits inflammation in rats by reducing serum IL-6 and TNF- α. Nat Prod Commun 2011;6:1545-8
15. Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta 2016;1863:2977-92.
16. World Health Organisation. Department of Chronic Diseases and Health Promotion. Preventing Chronic Diseases: A Vital Investment: WHO Global Report. Geneva: World Health Organization; 2005. p18.
17. Bast F, Rani P, Meena D. Chloroplast DNA phylogeography of holy basil (Ocimum tenuiflorum) in Indian subcontinent. ScientificWorldJournal 2014;2014:847‑482.
18. Singh N, Hoette Y, Miller R. Tulsi: The Mother Medicine of Nature. 2nd ed. Lucknow: International Institute of Herbal Medicine; 2010. p. 28‑47.
19. Mahajan N, Rawal S, Verma M, Poddar M, Alok S.A phytopharmacological overview on Ocimum species with special emphasis on Ocimum sanctum. Biomed Prev Nutr 2013;3:185- 92.
20. Mohan L, Amberkar MV, Kumari M. Ocimum sanctum linn. (TULSI)-an overview. Int J Pharm Sci Rev Res 2011;7: 51‑3.
21. Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacogn Rev 2010;4:95-105.
22. Mondal S, Mirdha BR, Mahapatra SC. The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J PhysiolPharmacol 2009;53:291-306.
23. Wangcharoen W, Morasuk W. Antioxidant capacity and phenolic content of holy basil. Songklanakarin J
24. Sci Technol 2007;29:1407‑15.
25. Panda VS, Naik SR. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Altern Med Rev 2009;14:161‑71.
26. Shivananjappa M, Joshi M. Aqueous extract of tulsi (Ocimum sanctum) enhances endogenous antioxidant defenses of human hepatoma cell line (HepG2). J Herbs Spices Med Plants 2012;18:331-48. Manikandan P, Murugan RS, Abbas H, Abraham SK, Nagini S. Ocimum sanctum
27. Linn. (Holy Basil) ethanolic leaf extract protects against 7,12‑dimethylbenz
(a) anthracene-induced genotoxicity, oxidative stress, and imbalance in xenobiotic- metabolizing enzymes. J Med Food 2007;10:495‑502.
28. Siddique YH, Ara G, Beg T, Afzal M. Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells. Acta Biol Hung 2007;58:397‑409.
29. Jha AK, Jha M, Kaur J. Ethanolic extracts of Ocimum sanctum, Azadirachta indica and Withania somnifera cause apoptosisin SiHa cells. Res J Pharm Biol Chem 2012;3:557‑62.
30. Manikandan P, Vidjaya Letchoumy P, Prathiba D, Nagini S.
31. Maxia A, Frau MA, Falconieri D, Karchuli MS, Kasture S. Essential oil of myrtuscommunis inhibits inflammation in rats by reducing serum IL-6 and TNF- α. Nat Prod Commun 2011;6:1545-8
32. Redza-Dutordoir M, Averill-Bates DA. Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta 2016;1863:2977-92.
33. Deuschle VC, Deuschle RA, Bortoluzzi MR, Athayde ML. Physical chemistry evaluation of stability, spreadability, in vitro antioxidant, and photo-protective capacities of topical formulations containing Calendula officinalis L. leaf extract. Braz J Pharm Sci 2015;51:63- 75.
34. Atta AH, Alkofahi A. Anti-nociceptive and antiinflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol 1998;60:117-24.
35. Vogel HG, Vogel WH. Drug Discovery and Evaluation, Pharmacological Assay. Berlin: Springer; 1997.
36. Medeiros R, Figueiredo CP, Passos GF, Calixto JB. Reduced skin inflammatory response in mice lacking inducible nitric oxide synthase. Biochem Pharmacol 2009;78:390-5.
37. .Xavier-Santos JB, Félix-Silva J, Passos JG, Gomes A, Fernandes JM, Garcia VB. Development of an effective and safe topical anti-inflammatory gel containing Jatropha gossypiifolia leaf extract: Results from a pre-clinical trial in mice. J Ethnopharmacol 2018;227:268-78.