Volume : 12, Issue : 12, December- 2025

Title:

FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM

Authors :

Mr. Akshay Madhukar Darade*, Mr. Amol G. Jadhao, Dr. Ashutosh Kumar Dash

Abstract :

Colon-targeted drug delivery systems have emerged as an essential platform for achieving site-specific therapy, improving drug bioavailability, and minimizing systemic side effects. Recent developments in polymer science, formulation engineering, and stimuli-responsive technologies have significantly enhanced the precision and efficiency of colonic drug delivery. These systems exploit physiological triggers such as pH gradients, microbial enzymes, transit time, and pressure differences to ensure controlled and targeted release of therapeutics. Advances in hybrid delivery platforms, nanotechnology-based carriers, and microbiome-responsive formulations further contribute to improved therapeutic outcomes, particularly in conditions such as inflammatory bowel disease, ulcerative colitis, colorectal cancer, and peptide or protein drug delivery. This article provides an in-depth examination of the developmental strategies, underlying mechanisms, and emerging applications of colon-targeted systems, emphasizing their potential to revolutionize localized and systemic drug delivery. The challenges and future prospects associated with clinical translation are also discussed.
Keywords: Colon-targeted drug delivery, site-specific release, stimuli-responsive systems, pH-dependent delivery, microbial-triggered release, polysaccharide-based systems, therapeutic applications, inflammatory bowel disease, colorectal cancer, controlled drug delivery.

Cite This Article:

Please cite this article in press Akshay Madhukar Darade et al., Formulation And Evaluation Of Colon Targeted Drug Delivery System, Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

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