39.Issue 12 december 25 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 12, Issue : 12, December- 2025

Title:

FORMULATION AND EVALUATION OF AN ANTIOXIDANT CREAM FOR PROTECTION AGAINST FREE RADICAL–INDUCED SKIN DAMAGE

Authors :

Radhika Suppadsing Jarwal, Manisha Dashrath Sonwane, Ashwini Dattu Sonwane, Sanjivani Nana Kale , Pooja Dinkar Jadhav

Abstract :

Oxidative stress caused by free radicals plays a major role in premature skin aging, inflammation, and various dermatological disorders. Antioxidants are capable of neutralizing reactive oxygen species and protecting skin cells from oxidative damage. The present study was aimed at the formulation and evaluation of an antioxidant cream intended for topical application. An oil-in-water (O/W) cream base was selected due to its non-greasy nature and better patient acceptability. The antioxidant was incorporated into the cream using a conventional emulsification method, ensuring stability and uniform distribution. The formulated cream was evaluated for physicochemical parameters such as appearance, pH, viscosity, spreadability, and content uniformity. In-vitro antioxidant activity was assessed using standard free radical scavenging assays. The developed antioxidant cream showed satisfactory physical characteristics, skin-compatible pH, good spreadability, and significant antioxidant activity. The results suggest that the formulated antioxidant cream has potential for topical use in protecting the skin against oxidative stress and related damage.
Keywords: Antioxidant cream; Oxidative stress; Free radicals; Topical formulation; Oil-in-water cream; Skin protection

Cite This Article:

Please cite this article in press Radhika Suppadsing Jarwal et al., Formulation And Evaluation Of An Antioxidant Cream For Protection Against Free Radical–Induced Skin Damage, Indo Am. J. P. Sci, 2025; 12(12).

Number of Downloads : 10

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