Volume : 12, Issue : 12, December- 2025
Title:
FORMULATION AND EVALUTION OF TERBINAFINE ANTI-FUNGA NANO GEL TOPICAL DRUG DELIVERY SYSTEM
Authors :
Mrs.Thurupu Sowmya* , Dr.Shoaeb Mohammad Syed
Abstract :
The aim of the present investigation was to formulate drug Terbinafine (TBH) encapsulated solid lipid nanoparticles (SLN) loaded in hyaluronic acid gel which have prolonged anti Fungal activity. The compatibility between the selected drugs and polymers has been studies using DSC and FTIR studies. The TBH-SLN have been prepared using Solvent evaporation method, Further confirmed by Box behnken design and evaluated for particle size, zeta potential, Fourier transform infrared analysis (FTIR), Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Atomic force microscopy (AFM) and X-ray powder diffraction(XRD) studies. These prepared nanoparticles are into Hyaluronic acid derivative gel (Na-Hy) and the final formulation was obtained. This Formulation is evaluated for pH, viscosity, Gelation time and temperature, Spreadibility, In bioadhesion, In vitro drug release, In vitro drug release, in vitro anti-fungal activity, In vivo irritation studies and in vivo anti-fungal activity. The results of compatibility studies between the drug and polymers revealed that both are compatible with each other without any unwanted interactions. Evaluation of TBH-SLN revealed that the nanoparticles formed have a particle size, zeta potential and EE of 264.9 nm, -27.7 mV and 70.09% respectively. The DSC and XRD studies of nanoparticles confirmed that conversion of crystalline to amorphous form of TBH. Further Morphology was also confirmed using AFM. Characterization of TBH-SLN loaded NA-Hy gel shows a optimized gel formulation with pH almost 4.2 matching vaginal pH, temperature of 3200C in compatible with the standard range and with an extended and prolonged release for about 42 hrs over In vitro drug release studies. It also showed noticeable decrease in the Colony forming units (CFU) of many Fungal strains esp. Candida albicans making it a promising gel formulation, further confirmed with In vivo studies over albino wistar rats. The present study tried to have a prolonged duration of action at the site of application which ensures longer adherence of drug. The prepared novel gel formulation satisfied the properties of an ideal gel in terms of gelation time, temperature, swelling, viscosity, biodegradation, biocompatibility, controlled release, anti-fungal properties which are crucial for prolonged drug release. Hence, the present study suggests that the synergistic combination of TBH loaded as SLN.
Keywords: Terbinafine, Solid lipid nanoparticles, Hyaluronic acid derivative, sodium hyaluronate, Gel formulation, Fungal infections, Prolonged drug release.
Cite This Article:
Please cite this article in press Thurupu Sowmya et al., Formulation And Evalution Of Terbinafine Anti-Funga Nano Gel Topical Drug Delivery System, Indo Am. J. P. Sci, 2025; 12(12).
Number of Downloads : 10
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