Volume : 12, Issue : 12, December- 2025
Title:
FORMULATION AND CHARACTERISATION OF GLYCYRRHIZA GLABRA EXTRACT ENRICHED HYDROGEL UNDER EYE PATCH
Authors :
Ms. Smitha John, Aleena Joseph K J, S Lekshmi, Chaithanya Sajeev, Alriza Parikochu
Abstract :
The purpose of this study was to create and describe a hydrogel eye patch enhanced with Glycyrrhiza glabra extract for the treatment of under-eye issues such puffiness, wrinkles, and dark circles. Due to its intricate and delicate structure, the under-eye area is more susceptible to ageing, environmental stress, and other conditions that can result in wrinkles, puffiness, and dark circles. Liquorice extract is a perfect active ingredient for treating under eye issues since it contains triterpenoid saponins and flavonoids, which have anti-oxidant, anti-inflammatory, and anti-hyperpigmentation qualities. The Glycyrrhiza glabra extract was prepared by maceration process and the hydrogel eye patches were developed by incorporating the liquorice extract into a gelatin matrix, along with key ingredients like hyaluronic acid for hydration, vitamin E for antioxidant protection, and phenoxyethanol as a preservative to extend shelf life. The extract was evaluated by determining organoleptic properties, phytochemical analysis, TLC, FT-IR and antioxidant assessment by DPPH assay. Three formulations of eyepatch were prepared and optimized for its physiochemical properties and F3 was selected as better formulation. Additionally, its efficacy was evaluated by determining pH, viscosity, compatibility and solubility. The physicochemical features of the prepared patches, which include viscosity, swelling ratio, and drug release characteristics, were assessed. Its continuous release profile, as demonstrated by in-vitro drug release tests, supports its possible effectiveness in reducing puffiness and enhancing skin texture. The extract’s DPPH study revealed 93.114% antioxidant activity, making it a perfect ingredient for treating puffiness, wrinkles, and dark circles. The hydrogel eye patch is stable, effective, and a viable therapeutic option for under eye issues, according to the results.
KEY WORDS: Glycyrrhiza glabra, Hydrogel eye patch, Under eye concerns, Antioxidant, DPPH Assay
Cite This Article:
Please cite this article in press Smitha John et al., Formulation And Characterisation Of Glycyrrhiza Glabra Extract Enriched Hydrogel Under Eye Patch, Indo Am. J. P. Sci, 2025; 12(12).
Number of Downloads : 10
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