Volume : 12, Issue : 12, December- 2025

Title:

FORMULATION AND EVALUATION OF SOLID SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM

Authors :

Vaibhav Ankush Vhatkar*, Shashwat Pravin Kulkarni, Aditi Anil Patil, Omkar Hanmant Palkar, Shreya Pramod hillal, Prachiti Vasant Katkar, Chaitanya Santosh Kokate

Abstract :

Poor aqueous solubility remains one of the most significant challenges in the oral delivery of modern drug molecules, particularly those belonging to Biopharmaceutics Classification System (BCS) Class II and IV. Self-microemulsifying drug delivery systems (SMEDDS) have emerged as an effective lipid-based approach to enhance solubility, dissolution rate, and oral bioavailability of such drugs by forming fine oil-in-water microemulsions upon gastrointestinal dilution. However, conventional liquid SMEDDS suffer from several formulation and manufacturing limitations, including poor physical stability, leakage, capsule incompatibility, and limited dosage form flexibility. These drawbacks have led to the development of Solid Self-Microemulsifying Drug Delivery Systems (S-SMEDDS), which combine the biopharmaceutical advantages of liquid SMEDDS with the technological and patient-centric benefits of solid dosage forms.
This review comprehensively discusses the fundamental principles of SMEDDS, rationale for solidification, selection of excipients, and various preparation techniques employed for S-SMEDDS. Detailed characterization and evaluation strategies, including physicochemical, solid-state, in-vitro, and in-vivo assessments, are critically reviewed. The applications of S-SMEDDS in improving the oral delivery of antidiabetic, anticancer, antifungal, antiviral, central nervous system drugs, and herbal phytoconstituents are also highlighted. Overall, S-SMEDDS represent a promising and industrially viable platform for enhancing oral bioavailability and therapeutic performance of poorly water-soluble drugs.
Keywords:Solid self-microemulsifying drug delivery systems; S-SMEDDS; Lipid-based drug delivery; Poorly water-soluble drugs; Oral bioavailability enhancement; BCS Class II and IV drugs; Solidification of SMEDDS.

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Number of Downloads : 10

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