Volume : 12, Issue : 02, February – 2025
Title:
IONTOPHORESIS USAGE IN DERMAL DELIVERY SYSTEMS
Authors :
A.V.S.Madhulatha*, Ch.V.Suresh, D.Guruswamy, G.Tejaswari, M.Anil, M.Bogeswarreddy
Abstract :
Iontophoresis is facilitated movement of ions across a membrane under the influence of an externally applied electric potential difference, is one of the most promising physical skin penetration enhancing method. Recently, there has been increased interest in using this technique for the transdermal delivery of medications, both ionic and nonionic. The rationale behind using this technique is the capability of this method to increase the systemic delivery of high molecular weight compounds with controlled input kinetics and minimum inter-subject variability, which is otherwise achieved only when parentral route of administration is used. Mechanism of iontophoretic transport of drugs across the skin involves either diffusion, migration or electroosmosis Various parameters which affect the transdermal absorption of drugs through iontophoresis like drug concentration, polarity of drugs, pH of donor solution, ionic strength, electrode polarity etc. have also been reviewed in detail. In therapeutic context, it is used to facilitate the administration of bioactive substances, either systemically or locally. The technique presents various advantages and that is why it has been successfully used by a plethora of medical sciences. The constantly developing field of dermato-cosmetic science has also taken advantage of the possibilities offered by iontophoresis, aiming to enhance the delivery of the applied active ingredients and, thus, induce the desired cosmetic effects.Iontophoresis can be safely and successfully used in the treatment of ageing, photoageing, hyperpigmentation, oxidative stress, hair loss, hair removal, acne, acne sequelae and cellulite, providing many possibilities for enhanced treatment results.
Cite This Article:
Please cite this article in press A.V.S.Madhulatha et al., Iontophoresis Usage In Dermal Delivery Systems., Indo Am. J. P. Sci, 2025; 12 (02).
Number of Downloads : 10
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