Volume : 12, Issue : 02, February – 2025
Title:
SPHERICAL CRYSTALLIZATION: AN INNOVATIVE TECHNIQUE IN THE FIELD OF PARTICLE ENGINEERING
Authors :
A.V.S.Madhulatha*, Ch.V.Suresh , A.Ruchitha,B.Manikanta ,U.Nani, K.Madhavi
Abstract :
In the manufacture of tablets, the direct compression method is frequently used. In comparison to the traditional wet granulation approach, this cannot be used with sensitive pharmaceuticals and also has a lot more processing restrictions. Spherical agglomeration is a innovative method for creating pharmaceutical dosage forms that are immediately compressible, the process of spherical agglomeration, which improves the powder’s qualities such as particle size, shape, flow characteristics, solubility, and bioavailability of pharmaceutical medicinal ingredients, includes transforming tiny crystals into a spherical shape. The spherical crystallization was improved for use with hydrophilic polymers in order to improve the dissolution properties of hydrophobic drugs. The flow characteristics, particle size analysis, compression, and dissolution behavior of the spherical agglomerates were also improved. Wet spherical agglomeration (WSA) and the quasiemulsion solvent diffusion method (QESD) are the two most used methods for crystallizing spheres. Additionally, these approaches have two additions: the ammonia diffusion system (ADS) and crystallo-coagglomeration (CCA).The neutralization technique is another method used in this procedure. Any of the aforementioned methods can be used concurrently for both crystallization and agglomeration This article describe the over view of spherical crystallization along with way of optimizing the processing parameters to get effective spherical agglomerates.
Keywords: Spherical agglomeration; Quasiemulsion solvent diffusion method; Ammonia diffusion system; Crystallo-co agglomeration
Cite This Article:
Please cite this article in press A.V.S.Madhulatha et al., Spherical Crystallization: An Innovative Technique In The Field Of Particle Engineering., Indo Am. J. P. Sci, 2025; 12 (02).
Number of Downloads : 10
References:
1. Hasiful Arabi J , Subramanian L , Rajesh .M.A review on spherical crystallization: A novel technique in the field of particle engineering. World Journal of Biology Pharmacy and Health Sciences, 2023; 13(01): 078-093.
2. Jyothi Thati, Sailu Chinta. A Review on Spherical Crystallization Mechanisms and Characterization. Research J. Pharm. and Tech. 2018; 11(1): 412-417.
3. Chatterjee A, Gupta MM, Srivastava B. Spherical crystallization: A technique use to reform solubility and flow property of active pharmaceutical ingredients. Int J Pharm Investig. 2017 ;7(1):4-9.
4. Pusapati RT, Kumar MK, Rapeti SS, Murthy T. Development of co-processed excipients in the design and evaluation of atorvastatin calcium tablets by direct compression method. Int J Pharm Investig 2014;4:102-6..
5. Dixit M, Kulkarni PK, Vaghela RS. Effect of different crystallization techniques on the dissolution behavior of ketoprofen. Trop J Pharm Res 2013;12:317-22.
6. Tahara K, O’Mahony M, Myerson AS. Continuous spherical crystallization of albuterol sulfate with solvent recycle system. Cryst Growth Des. 2015;15:5155–6.
7. Patil SV, Sahoo SK. Pharmaceutical overview of spherical crystallization Research Library. Der Pharmacia Lettre, 2010; 2 (1) : 421-426.
8. Imroz S.M., Shaik Firoz, Chandramouli Y, Chakrapani M. A review on spherical crystallization: a novel particle design technique for direct compression of pharmaceutical powders. 2012;2(2):113-121.
9. Kawashima Y, Imai M, Takeuchi H, Yamamoto H, Kamiya K, Hino T. Improved flowability and compactibility of spherically agglomerated crystals of ascorbic acid for direct tableting designed by spherical crystallization process. Powder Technol 2003;130: 283– 289.
10. Ujwala R, Redasani K, Kothwade S. Preparation and in-vitro evaluation of loperamide hydrochloride spherical crystals by emulsion solvent diffusion technique. Int J Pharm PharmSci 2013;5:409-13..
11. Sano A, Kuriki T, Kawashima Y, Takeuchi H, Hino T, Niwa T. Particle design of tolbutamide by spherical crystallization technique. V. Improvement of dissolution and bioavailability of direct compressed tablets prepared using tolbutamide agglomerated crystals. Chem Pharm Bull. 1992; 40: 3030–3035.
12. Kawashima Y, Cui F, Takeuchi H, Hino T, Niwa T, Kiuchi K. Parameters determining the agglomeration behavior and the micrometric properties of spherically agglomerated crystals prepared by spherical crystallization technique with miscible solvent system. Int J Pharm. 1995; 119: 139-147.
13. Sano A, Kuriki T, Kawashima Y, Takeuchi H, Hino T, Niwa T.Particle design of Tolbutamide by the spherical crystallization technique IV, Improved of dissolution and bioavailability of direct compression tablets prepared using Tolbutamide agglomerated crystals, Chem. Pharm. Bull. 1992; 40: 3030-3035.
14. Shashank T , Prerana V. Spherical crystallization –A novel drug delivery system.Int. J. of Pharm. & Life Sci. 2011; 2(9): 1065-1068.
15. Deshpande MC, Mahadik KR, Pawar AP and Paradkar AR . Evaluation ofspherical crystallization as particle size enlargement technique for Aspirin.Ind.J.Pharm.Sci 1997; 59 (1): 32-34.
16. Kawashima Y, Cui F, Takeuchi H, Hino T, Niwa T and Kiuchi K.Improved static compression behavior of tablettabilities of spherically agglomerated crystals produced by the spherical crystallization technique with two solvent system.Pharm.Res.1995;12:1040-44.
17. Kawashima Y, Takeuchi H, Hino T, Niwa T and Kiuchi K . Improvement in flowability and compressibility of pharmaceutical crystals for direct tabletting by spherical crystallization with a two solvent system. Powder Technology.1994; 78:151-157.
18. Kachirmanis K, Ktistis G and Malamatris S .Crystallization conditions and physico-chemical properties of Ibuprofen-Eudragit S-100 spherical crystal agglomerates prepared by solvent change technique. Int.J.Pharm.1998; 173: 61-74.
19. Morishima K, Kawashima Y, Takeuchi H, Niwa T, Hino T. Tabletting properties of bucillamine agglomerates prepared by the spherical crystallization technique. Int. J. Pharm.1994; 105:11-18.
20.Martino PD, Barthelemy C, Piva F, Joiris E and Marthelemy C. Improved dissolution behavior of Fenbufen by spherical crystallization. Drug Dev.Ind.Pharm. 1995: 25 (10); 1073-1081.