Volume : 12, Issue : 02, February – 2025

Title:

A STUDY ON PREVALANCE, CLINICAL PROFILE AND DRUG USE PATTERN OF NEPHROTIC SYNDROME IN CHILDREN ADMITTED IN PEDIATRIC DEPARTMENT, GOVERNMENT GENERAL HOSPITAL KURNOOL.
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Authors :

R. Jona Methusula, V. Venkateswari, G. Naga Vinugna, S. Navya Sree Anusha, M. Hanumanth Reddy

Abstract :

Aim: The study mainly aims to assess the drug use pattern of the treatment prescribed and the prevalence, clinical profile of the patients diagnosed with Nephrotic syndrome.
Objective: The main objective is to study the drug use pattern in Nephrotic syndrome in-patients attending the paediatrics department.
•To assess changes in trends of Drug utilization in Nephrotic syndrome patients, clinical profile and prevalence of Nephrotic syndrome in tertiary care hospital.
•To assess the drug regimen used in different clinical conditions.
Methodology: This study is a prospective observational study and the subjects involved are the In-patient Paediatrics department at Government General Hospital, Kurnool. All the patients satisfying the inclusion criteria were selected from the paediatrics department of Government General Hospital, Kurnool.
Results: In this study, total of 120 patients were included. The demographic distribution of patients with nephrotic syndrome reveals a slightly higher enrolment of males (65) compared to females (55). Among these patients, those aged between 5 to 10 years constitute the largest group (55), followed by the 1 to 4 years age group (48), and those older than 10 years (17). Clinical symptoms predominantly include facial puffiness (100), abdominal distension (80), decreased urine output (77), and edema (97). Regarding edema types, periorbital (97) and pedal (70) oedema is particularly notable. A total of 120 patients the episodes of Nephrotic Syndrome vary, with 60 patients experiencing a single episode, 44 patients experiencing two, and 16 patients were experiencing more than three episodes. The most frequently prescribed antibiotic is ceftriaxone (70). Additionally, nephrotic syndrome patients often require antihypertensive therapy, with nifedipine being the predominant choice (73). Gastroprotective therapy primarily involves pantoprazole (82).
Conclusion: In this comprehensive study of 120 patients with nephrotic syndrome, a clear depiction of demographic distribution, clinical presentation, and treatment patterns emerges. Males were notably more prevalent than females, consistent with prior research, and certain age groups, particularly those between 1 to 4 years, were more affected. Periorbital edema was the most common type observed, with facial puffiness and edema being chief presenting symptoms. The frequency of episodes varied, with a subset experiencing recurrent or persistent nephrotic syndrome and Treatment strategies predominantly included immunosuppressants and antibiotics, with prednisolone being the primary choice, alongside supportive therapies like diuretics and gastroprotective.
These findings underscore the multifaceted nature of managing nephrotic syndrome, highlighting the importance of tailored therapeutic approaches to address both clinical symptoms and underlying pathology.
Keywords: Nephrotic syndrome, Immunosuppressants, Drug utilization pattern.

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