Volume : 12, Issue : 02, February – 2025
Title:
FORMULATION AND EVALUATION OF FENUGREEK GEL FOR ANTI INFLAMMATORY ACTIVITY
Authors :
Manjula T., Nirosha C., Nandhini D., Revathi V., Kokila
Abstract :
Fenugreek (Trigonella foenum-graecum) has been traditionally used for its anti-inflammatory and medicinal properties. The aim of this study was to formulate and evaluate a topical gel of fenugreek extract using natural polymers for anti-inflammatory activity. Fenugreek extract was obtained through solvent extraction and characterized for its phytoconstituents. A gel formulation was prepared using the extract and natural polymers such as carrageenan and xanthan gum. The formulated gel was evaluated for its physicochemical properties, in vitro drug release, and anti-inflammatory activity using the carrageenan-induced paw edema method. The optimized gel formulation showed satisfactory physicochemical properties and in vitro drug release. The anti-inflammatory activity of the gel was found to be significant (p < 0.01) compared to the control group, with a maximum inhibition of 61.23%. The study demonstrates the potential of fenugreek extract gel as a topical anti-inflammatory agent. The use of natural polymers in the formulation provides a safe and biocompatible delivery system for the extract.
Further studies are warranted to explore the clinical efficacy and safety of the formulation. Fenugreek contains compounds that promote tissue regeneration and wound closure. It may protect wounds from bacterial infections, aiding faster recovery.
Keywords: Fenugreek extract, natural polymer, anti-inflammatory activity, topical gel, Wound healing
pattern.
Cite This Article:
Please cite this article in press Manjula T et al., Formulation And Evaluation Of Fenugreek Gel For Anti Inflammatory Activity.,Indo Am. J. P. Sci, 2025; 12 (02).
Number of Downloads : 10
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