Volume : 12, Issue : 02, February – 2025
Title:
IN-VITRO EVALUATION OF ANTI-PARKINSONISM ACTIVITY OF Musa acuminata ‘Red Dacca’
Authors :
Adarsh Krishnan U A *, Ajisha A J *, Achu Prasannan *, Dr. Kiran K J *,Mrs. Sanitha M *, Dr. Prasobh G R *
Abstract :
The present study aimed to evaluate the anti- Parkinson’s potential of ethanolic extract of Musa acuminata ‘Red Dacca’ fruit using in vitro methods. Musa acuminata ‘Red Dacca’ fruit were collected, chopped, shade dried and then finally powdered.
The ethanolic extract of Musa acuminata ‘Red Dacca’ were prepared by using ethanol followed by maceration method. Preliminary phytochemical screening was performed by using standard operating procedures. The anti-Parkinson’s activity of plant extract was assessed by using in vitro studies. Invitro studies are performed by 3-(4,5-dimethylthiazol-2yl)-2,5 diphenyl tetrazolium bromide [MTT assay].
The preliminary phytochemical analysis indicated the presence of amino acids, phenolic compounds, carbohydrates, flavonoids. The extract inhibits cytotoxicity. In this study, the results demonstrated that the ethanolic extract of Musa acuminata ‘Red Dacca’ fruit possess anti-Parkinson’s activity.
Keywords: Anti-Parkinson’s activity, Musa acuminata ‘Red Dacca’, Invitro studies, Dopamine, Chemical Constituents, MTT assay
Cite This Article:
Please cite this article in press Adarsh Krishnan U A et al., In-Vitro Evaluation Of Anti-Parkinsonism Activity Of Musa acuminata ‘Red Dacca’.,Indo Am. J. P. Sci, 2025; 12 (02).
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References:
1. Aravind Kumar Shakya. Medicinal plants: Future source of new drugs. International Journal of Herbal Medicine. 2016; 4(4): 59-64.
2. Dorsey ER, Constantinescu R, Thompson JP. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology.2007; 68: 384–386.
3. Adler CH. Nonmotor complications in Parkinson’s disease. Mov Disord .2005;20: S23–S29.
4. Aline Pereira, Marcelo Maraschin. Banana (Musa species) from peel to pulp: Ethnopharmacology, source of bioactive compounds and its relevance from human health. Journal of Ethnopharmacology. 2015; 160: 149-163.
5. Jiwan S Sidhu, Tasleen A Zafar. Bioactive compounds in banana fruits and their health benefits. Food quality and safety. 208; 2:182-188.
6. Simmonds, N.W. A comprehensive reference on banana species, their origin, taxonomy, and cultivars, including the Red Banana”. Botanical Review. 1955; 21(1): 1–17.
7. Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and Extraction: A Review. International Pharmaceutical Science, 2011; 1(1): 98- 106.
8. Jerard C, Michael BP, Chenicheri S, Vijayakumar N, Ramachandran R. Rosmarinic Acid-Rich Fraction from Mentha arvensis Synchronizes Bax Expression and Induces Go/G1 Arrest in Hepatocarcinoma Cells. PNAS, India, Sect B Bio Sci. 2020; 90(3): 515–22.
9. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods. 1983; 65(1–2):55–63.