Volume : 12, Issue : 02, February – 2025

Title:

STUDY OF EFFECTIVENESS OF HEPATOPROTECTIVE AGENTS AND ANTIMICROBIALS IN THE TREATMENT OF LIVER DISEASES
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Authors :

Yall Hemalatha *, M.Madhavi Kumara

Abstract :

This study aimed to evaluate the effectiveness of hepatoprotective agents and antibiotics in managing liver diseases. A total of 78 subjects were divided into two groups: Group 1 (n=39) received both hepatoprotective and antimicrobial agents, while Group 2 (n=39) received only hepatoprotective agents. Liver function tests (LFTs) were assessed before and after treatment.
Demographically, the study included more males (68%) than females (32%), with most participants aged above 55 years. A majority (52%) were from rural areas, and educational qualifications varied widely. The primary liver diseases observed included hepatitis, fibrosis, cirrhosis, and liver failure, with cirrhosis being the most common. Social history revealed that alcohol consumption was prevalent among participants.
Regarding treatment, 18 subjects received Udiliv, 30 received Hepamerz, and 30 received both. Symptoms, including abdominal discomfort, significantly decreased post-treatment, especially in Group 1, which received antibiotics. LFT results indicated that total bilirubin, direct bilirubin, indirect bilirubin, and alkaline phosphatase levels improved more in Group 1 than in Group 2. Other parameters such as AST, ALT, total protein, albumin, globulin, and A/G ratio showed minimal variations between groups.
Overall, the combination of hepatoprotective and antimicrobial agents demonstrated better efficacy in reducing symptoms and improving liver function markers compared to hepatoprotective agents alone. These findings align with previous studies on the efficacy of antibiotics and hepatoprotective agents in liver disease management.
Keywords: hepatoprotective, antimicrobial agents, total bilirubin, direct bilirubin, indirect bilirubin, and alkaline phosphatase levels

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