Volume : 12, Issue : 01, January – 2025
Title:
SYNTHESIS, CHARACTERIZATION AND EVALUATE THE BIOLOGICAL ACTIVITY OF SOME OF SUBSTITUTED IMIDAZOLE DERIVATIVES
Authors :
Thukuntla Ramya Krishna *, Dr.B. Sudhakar, Dr.K. Chaitanyaprasad, Dr.K. Shravankumar
Abstract :
The preliminary studies on antimicrobial activity of the new imidazole derivatives have generated some interesting data. An attempt has been made to infer the ultimate outcome of the present studies basing on this data.The compounds were confirmed by TLC, melting point and spectral studies such as FT-IR, MS, and 1H NMR. All the synthesized new imidazole derivatives were evaluated for antibacterial activity by using standard ciprofloxacin, antifungal activity by using standard fluconazole and antioxidant activity by using ascorbic acid.
Synthetic work of the studies could go positively as per the planning and as such in all the reactions carried out. The expected compounds alone could be obtained. Newly synthesized compounds were characterized by TLC, IR, ¹H-NMR and Mass spectral analysis.New imidazole derivatives showed promising antimicrobial activity. Compounds Methyl and Fluorine imidazole derivatives were found to be the more potent antibacterial activity respectively towards gram positive (Micrococcus luteus) and gram negative (klebsiella pneumonia) New imidazole derivatives showed promising antioxidant activity. Compounds (R=F) & (R= CH3) were found to be more potent antioxidant compounds among the all-test compounds.
Cite This Article:
Please cite this article in press Thukuntla Ramya Krishna et al., Synthesis, Characterization And Evaluate The Biological Activity Of Some Of Substituted Imidazole Derivatives.,Indo Am. J. P. Sci, 2025; 12 (01).
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