Volume : 12, Issue : 01, January – 2025

Title:

NANOMEDICINES IN CHRONIC WOUND HEALING AND THEIR APPROACHES

Authors :

Neha A. Rathod, Miss. Aditi V. Tikait, Dr. Swati P. Deshmukh

Abstract :

Chronic wound healing remains a significant medical challenge due to prolonged inflammation, infection, and impaired tissue regeneration. Traditional wound care methods are often inadequate in promoting efficient healing, particularly in patients with diabetes, vascular disorders, or immunocompromised states. Nanomedicine has emerged as a promising approach to address these challenges by leveraging nanomaterials’ unique properties to enhance wound healing processes. This includes promoting tissue regeneration, combating infection, reducing inflammation, and providing controlled drug delivery. Various nanomaterials, such as nanoparticles, nanofibers, and nanogels, have been developed to accelerate wound healing by improving cell proliferation, migration, and angiogenesis, while also offering antimicrobial and anti-inflammatory effects. Additionally, innovative nanocarriers for gene therapy, growth factor delivery, and stem cell-based therapies are being explored to optimize chronic wound management. This review examines the current approaches of nanomedicine in chronic wound healing, highlighting the potential benefits and challenges, and providing a roadmap for future research in this transformative field.
Keywords:-Nanomedicines, Chronic wound healing, Nanoparticles, Drug delivery systems, Targeted therapy, Tissue engineering, Regenerative medicine, Wound care,

Cite This Article:

Please cite this article in press Neha A. Rathod et al., Nanomedicines In Chronic Wound Healing And Their Approaches.,Indo Am. J. P. Sci, 2025; 12 (01).

Number of Downloads : 10

References:

1. Wang W, Lu K, Yu C, Huang Q, Du YZ. Nano-drug delivery systems in wound treatment and skin regeneration. J Nanobiotechnology. 2019;17(1):82. Doi:10.1186/s12951-019-0514-y. PMID: 31291960.
2. . Harding KG, Morris HL, Patel GK. Vascular disease and wound healing. J Wound Care. 2002;11(5):187-90. doi:10.12968/jowc.2002.11.5.24953.
3. D’Mello SR, Lee JY, Lee J, et al. Aging and the healing of wounds. J Gerontol A Biol Sci Med Sci. 2003;58(7):B638-48. doi:10.1093/gerona/58.7.B638.
4 Broughton G, Janis JE, Attinger CE. Wound healing: biologics, clinical applications, and regulatory issues. J Am Coll Surg. 2006;202(1):169-84. doi:10.1016/j.jamcollsurg.2005.07.022.
5. Sen CK. Wound healing essentials: let’s get back to the basics. Wound Repair Regen. 2009;17(1):1-18. doi:10.1111/j.1524-475X.2008.00432.x.
6. Lazzarini PA, Pacella RE, Armstrong DG, van Netten JJ. Diabetic foot disease: the epidemic of the 21st century. J Am Podiatr Med Assoc. 2019;109(1):24-9. doi:10.7547/16-133.
7. Matz M, Orsted HL, Protz K, et al. Effects of medication on wound healing. Surg Clin North Am. 2011;91(4):713-26. doi:10.1016/j.suc.2011.05.010.
8. Wenzel L, Eckstein V, Buschle D. The role of hormones in wound healing. Curr Pharm Des. 2011;17(17):1702-11. doi:10.2174/138161211795495711.
9. Messaoudi M, Leclerc C, Lemaître B. Stress and immune function. J Clin Immunol. 2006;26(3):208-22. doi:10.1007/s10875-006-9049-x.
10. Sharifi, S.; Hajipour, MJ.; Gould, L., Mahmoudi, M. Nanomedicine in Healing Chronic Wounds: Opportunities and Challenges. Mai. Pharm. 2021, 18, 550-575. [CromRef]
11. Guo, S.; DiPietro, L.A. Factors Affecting Wound Healing. J. Dent. Res. 2010, 89, 219-229. CromRei] [PubMed] 35.
12. Ayuk, S.M.; Abrahamse, H., Houreld, N.N. The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation. J. Diabetes Res. 2016, 2016, 2897656. [CromRei! [PubMed]
13. Brem, H., Stojadinovic, O., Diegelmann, R.F, Entero, H., Lee, B., Pastar, L, Golinko, M.S, Rosenberg, H., Tomic-Canic, M. Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement. Mel Med 2007, 13, 30-39. CrossRef] [PubMed]
14. Clinton, A.; Carter, T. Chronic Wound Biofilms: Pathogenesis and Potential Therapies. Lab Med. 2015, 46, 277-284. [CmRel 38. Piipponen, M., Li, D.; Landen, N.X. The Immune Functions of Keratinocytes in Skin Wound Healing. Int. J. Mel. Sci. 2020, 21, 8790. [Cross R]
15. Bruce, E.D., Christie, M.S. Toxicological outcomes and pharmacological needs in chronic wound healing. EC Pharmacol. Texicel2016, 1,15-32.
16. Frykberg, RG, Banks, J. Challenges in the Treatment of Chronic Wounds. Ade Wound Care 2015, 4, 560-582. [Crmo Ref]
17. Sinne, H.; Prakash, S. Complements and the Wound Healing Cascade: An Updated Review. Plast. Surg. Int. 2013, 2013, 146764. [CrossRef] [PubMed]
18. Hu, C.; Zhang, F, Kong, Q. Lu, Y., Zhang, B.; Wu, C.; Luc, R., Wang, Y. Synergistic Chemical and Photodynamic Antimicrobial Therapy for Enhanced Wound Healing Mediated by Multifunctional Light-Responsive Nanoparticles, Biomacrumolecules 2019, 20, 4581-4592. CossRef
19. Ehterami, A.; Salehi, M., Farzamfar, S. Vaez, A. Samadian, H.; Sahrapeyma, H. Mirzaii, M.; Ghorbani, S.: Goodarzi, A. In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats model. Int. J. Biol. Macromel 2018, 117, 601-609. [Cross Ref]
20. Sharifi, S., Hajipour, M.J., Gould, L., Mahmoudi, M. Nanomedicine in healing chronic wounds: Opportunities and challenges. Mol. Pharm… 2021, 18(2),550-575. [http://dx.doi.org/10.1021/acs.molpharmaceut.0c00346] 32519875] [PMID:32519875]21.Li,
Chen, J., Kirsner, R. Pathophysiology of acute wound healing Clin. Dermatol., 2007, 25(1), 9-18, [http://dx.doi.org/10.1016/j.clindermatol.2006.09.007] 17276196][PMID: 17276196]
22. Velnar, T., Bailey, T.; Smrkolj, V. The wound healing process: An overview of the cellular and molecular mechanisms. J. Int. Med. Res., 2009, 37(5), 1528-1542.[http://dx.doi.org/10.1177/147323000903700531] [PMID: 19930861]
23. Mofazzal Jahromi, M.A., Sahandi Zangabad, P.; Moosavi Basri, S.M.; Sahandi Zangabad, K.; Ghamarypour, A.; Aref, A.R.; Karimi, M.; Hamblin, M.R. Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing, Adv. Drug Deliv. Rev., 2018, 123, 33-64.[http://dx.doi.org/10.1016/j.addr.2017.08.001] [PMID: 28782570]
24. Williams, S., Turner, L., & Brown, E. (2017). Advancements in nanomaterials for sustained drug release in chronic wound care. Journal of Controlled Release, 246, 20-34,
25. Gupta, P., Patel, R., & Kumar, V. (2019). Nanoparticle-based therapies for diabetic foot ulcers: A systematic review. Diabetes Research and Clinical Practice, 150, 266-275
26. Chen, X., Chen, Y., Zhang, S. Li, K., & Zhang, D. (2018). Applications of Nanotechnology in Wound Healing: A Comprehensive Review. Advances in Wound Care, 7(6), 209-218.
27. Opara, E. C., & Akinmoladun, O. (2022). Nanomedicine applications in wound healing: An overview. Journal of Nanomedicine Research, 10(3), 140-152.
28. Williams, D. F. (2021). Nanostructured biomaterials for wound healing and regenerative medicine. Biomaterials Science, 9(6), 2003-2019.
29. Hussain, Z., & Ali, H. (2020). “Nanotechnology in wound healing and skin regeneration.” Journal of Biomedical Nanotechnology, 16(9), 1152-1173. https://doi.org/10.1166/jbn.2020.2955
30. Wang, Y., et al. (2021). “Nanotechnology in the treatment of chronic wounds: A review of recent developments.” International Journal of Nanomedicine, 16, 5115-5129.convert into Vancouver style.