Please cite this article in press Sakshi P. Tayade et al., A Comprehensive Review On The Tinospora Cordifolia (Giloy): The Multipurpose Medicinal Plant.,Indo Am. J. P. Sci, 2025; 12 (01).

1. Jayswal, M.G. “A comprehensive review on Tinospora cordifolia (Giloy): The medicinal plant.” International Journal of Multidisciplinary Research and Development, vol. 8, no. 6, 2021, pp. 80-85. Online ISSN: 2349-4182, Print ISSN: 2349-5979. Accessed on [date of access]. Available at: www.allsubjectjournal.com.
2. Gupta, Priyanka. “A Review on Therapeutic Multipurpose Medicinal use of Tinospora Cordifolia.” International Journal of Trend in Scientific Research and Development (ijtsrd), vol. 3, no. 5, August 2019, pp. 2115-2119. ISSN: 2456-6470. Available: https://doi.org/10.31142/ijtsrd27859.
3. Sinha, K., Mishra, N.P., Singh, J., Khanuja, S.P.S. “Tinospora cordifolia (Guduchi), a reservoir plant for therapeutic applications: A Review,” 2004.Mittal, J., Sharma, M.M., Batra, A. “Tinospora cordifolia: a multipurpose medicinal plant—A review,” Journal of Medicinal Plants Studies, vol. 2, no. 2, pp. 32-47, 2014. [Online]. Available: www.plantsjournal.com.
4. Timboli F.A. “An Immunity Booster for Pandemic Covid-19,” Tropical Journal, vol. 8, pp. 1-9, 2021.
5. Pandey, V., Vaishya, J.K., Balakrishnan, P., Nesari, T.M. “Nutritional aspects of Tinospora cordifolia (Giloe),” Medicinal Plants, vol. 12, no. 1, pp. 158-160, 2020. Doi: 10.5958/0975-6892.2020.00021.0.Nagarkatti, R., Rege, N., Desai, N., Dahanukar, S. “Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage,” Journal of Postgraduate Medicine, vol. 40, no. 2, p. 65, 1994. [Online]. Available: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1994;volume=40;issue=2;spage=65;epage=7;aulast=nagarkatti.
6. Bhide, M. M., & Nitave, S. A. (2022). Gulvel health benefits. World Journal of Pharmacy and Pharmaceutical Sciences, 11(4), 354-366. SJIF Impact Factor 7.632. ISSN 2278–4357.
7. Kumar, A., Jnanesha, A. C., & Nagaraju, S. Cultivation and Medicinal Properties of Giloy [Tinospora cordifolia (Thunb.) Miers], Vol. XVIII, Issue 01.
8. Modi, B., Shah, K. K., Shrestha, J., Shrestha, P., Basnet, A., Tiwari, I., & Aryal, S. P. Morphology, Biological Activity, Chemical Composition, and Medicinal Value of Tinospora Cordifolia (willd.) Miers, Advanced Journal of Chemistry, Section B, 2021; 3(1): 36-53.
9. D. Kumar, V. Geethanjali, B. Avinash, J. Kumar, G. Chandrashekrappa, and M. Basalingappa, “Tinospora cordifolia: The antimicrobial property of the leaves of amruthaballi,” Journal of Bacteriology & Mycology: Open Access, vol. 5, no. 5, 2017.
10. Mittal, J., Sharma, M. M., & Batra, A. (2014). Tinospora cordifolia: a multipurpose medicinal plant – A review. Journal of Medicinal Plants Studies, 2(2), 32–47. ISSN: 2320-3862. Available online: www.plantsjournal.com.
11. Reddy, N. M., & Reddy, R. N. Tinospora cordifolia Chemical Constituents and Medicinal Properties: A Review. Scholars Academic Journal of Pharmacy, 2015, 4(8), 364-369.
12. Yoggeta, Bhatia, D., & Rani, S. (2021). Tinospora Cordifolia: A literature review on therapeutic uses and pharmacological actions. Journal of Pharmaceutical Research International, 33(57A), 330-343. Article no.JPRI.77562. ISSN: 2456-9119.
13. Upadhaya AK, Kumar K, Kumar A, Mishra HS. Tinospora cordifolia (Willd.) Hook. F. And Thoms. (Guduchi)—validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res. 2010;1:112-121.
14. Rout GR. Identification of Tinospora cordifolia (Willd.) Miers ex Hook F & Thoms using RAPD markers. Z Naturforsch C. 2006;61:118-122.
15. Patel SS, Shah RS, Goyal RK. Antihyperglycemic, anti-hyperlipidemic and antioxidant effects of Dihar, a poly herbal Ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp Biol. 2009;47:564-570.
16. Gupta R, Sharma V. Ameliorative effects of Tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin B1 in mice kidney. Toxicol Int. 2011;18:94-98.
17. Jagetia GC, Rao SK. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma bearing mice. Biol Pharm Bull. 2006;29:460-466.
18. Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine. 2011;18:1045-1052.
19. Sriramaneni RN, Omar AZ, Ibrahim SM, Amirin S, Mohd ZA. Vasorelaxant effect of diterpenoid lactones from Andrographis paniculata chloroform extract on rat aortic rings. Pharmacognosy Res. 2010;2:242-246.
20. Yang S, Evens AM, Prachand S, Singh AT, Bhalla S, Devi K, et al. Diterpenoid lactone andrographolide, the active component of Andrographis paniculata. Clin Cancer Res. 2010;16:4755-4768.
21. Zhao F, He EQ, Wang L, Liu K. Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level. J Asian Nat Prod Res. 2008;10:467-473.
22. Kohno H, Maeda M, Tanino M, Tsukio Y, Ueda N, Wada K, et al. A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis. Cancer Lett. 2002;183:131-139.
23. Dhanasekaran M, Baskar AA, Ignacimuthu S, Agastian P, Duraipandiyan V. Chemopreventive potential of epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. Invest New Drugs. 2009;27:347-355.
24. Ly PT, Singh S, Shaw CA. Novel environmental toxins: Steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases. J Neurosci Res. 2007; 85:231-237.
25. Umamaheswari, S., & PS Mainzen Prince. (2007). Antihyperglycaemic effect of ‘Ilogen-Excel’, an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus. Acta Pol. Pharm, 64(1), 53-61.
26. Karpova EA, Voznyi YV, Dudukina TV, Tsvetkva IV. 4-Trifluoromethylumbelliferyl glycosides as new substrates for revealing diseases connected with hereditary deficiency of lysosome glycosidases. Biochem Int. 1991; 24:1135-1144.
27. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol. 1997; 58:89-95.
28. Chen S, Wu K, Knox R. Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2). Free Radic Biol Med. 2001; 29:276-284.
29. Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappa B. J Clin Invest. 2001; 107:241-246.
30. Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, et al. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry. 2010; 71:641-647.
31. Kim SK, Kim HJ, Choi SE, Park KH, Choi HK, Lee MW. Antioxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg. Arch Pharm Res. 2008; 31:424-428.
32. Lv J, Xu D, Perkovic V, Ma X, Johnson DW, Woodward M, et al. Corticosteroid therapy in IgA nephropathy. J Am Soc Nephrol. 2012; 23:1108-16.
33. McKeown E, Bykerk VP, Deleon F, Banner A, Thorne C, Hitchon CA, et al. Quality assurance study of the use of preventative therapies in glucocorticoid-induced osteoporosis in early inflammatory arthritis: results from the CATCH cohort. Rheumatology (Oxford). 2012; 51:1662-9.
34. Sundarraj S, Thangam R, Sreevani V, Kaveri K, Gunasekaran P, Achiraman S, et al. Γ-Sitosterol from Acacia nilotica L. Induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J Ethnopharmacol. 2012; 141:803-9.
35. Maurya R, Handa SS. Tinocordifolin, a sesquiterpene from Tinospora cordifolia. Phytochemistry. 1998; 49:1343-1346.
36. De-Oliveira, A. M., Conserva, L. M., De-Souza Ferro, J. N., De-Almeida Brito, F., Lyra-Lemos, R. P., & Barreto, E. (2012). Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. Grisea in mice. International Journal of Molecular Sciences, 13, 1598-1611.
37. Wang, T., Liu, Y. Y., Wang, X., Yang, N., Zhu, H. B., & Zuo, P. P. (2010). Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGP and NGF signalling. Acta Pharmacologica Sinica, 31, 765-774.
38. Thippeswamy, G., Sheela, M. L., & Salimath, B. P. (2008). Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-κB and its DNA binding activity. European Journal of Pharmacology, 588, 141-150.
39. Ghosh, A. K., Chapsal, B. D., Webar, I. T., & Mitsuya, H. (2008). Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance. Accounts of Chemical Research, 41, 78-86.
40. Mukherjee, R., De, U. K., & Ram, G. C. (2010). Evaluation of mammary gland immunity and therapeutic potential of Tinospora cordifolia against bovine subclinical mastitis. Tropical Animal Health and Production, 42, 645-651.
41. Kumari, P., et al. “Effect of Giloy (Tinospora cordifolia) and Neem (Azadirachta indica) on Growth Performance of Marwari Lambs Under Arid Zone.” Journal of Entomology and Zoology Studies, 2020, vol. 8, no. 3, pp. 849-852. [Online]. Available: http://www.entomoljournal.com.
42. Shree, P. “Targeting COVID-19 (SARS-CoV-2) Main Protease Through Active Phytochemicals of Ayurvedic Medicinal Plants—Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy), and Ocimum sanctum (Tulsi)—A Molecular Docking Study.” Journal of Biomolecular Structure and Dynamics, 2020, vol. 0, no. 0, pp. 1-14. Doi: 10.1080/07391102.2020.1810778.
43. Nazir, I., and Chauhan, R. S. “Qualitative Phytochemical Analysis of Tinospora cordifolia and Withania somnifera.” Pharma Innovation Journal, 2018, vol. 7, no. 10, pp. 333-336.
44. Singh, N. A., Kumar, P., Jyoti, and Kumar, N. “Spices and Herbs: Potential Antiviral Preventives and Immunity Boosters During COVID-19.” Phytotherapy Research, no. December 2020, 2021, pp. 1-13. Doi: 10.1002/ptr.7019.
45. Sarangi, M. K., and Soni, S. “A Review on Giloy: The Magic Herb.” [No volume], March 2013, 2015.
46. Singh, D. “One Plant, Abundant Roles: Tinospora cordifolia Accentuating the Hidden World of Microbiome During COVID-19.” [No volume], [Online]. Available: https://krishiscience.in/.
47. Soni, S. “A Review on Giloy: The Magic Herb Floating Emulsion Beads of Gelucire for Metronidazole and Norfloxacin.” 2013. [Online]. Available: https://www.researchgate.net/publication/275346992.
48. Rawat, S. “Preparation of Giloy Bark Incorporated Orange Squash.” [No volume], 2020, vol. 8, no. 2, pp. 26-31.
49. R. Verma, H. Singh, and R. C. Agrawal, “Evaluation of anticarcinogenic and antimutagenic effect of Tinospora cordifolia in experimental animals,” J. Chem. Pharmaceut. Res., vol. 3, pp. 877–881, 2011.
50. A. Shamim, T. Mahmood, H. H. Siddiqui, P. Bagga, and S. Roy, “Effect of Tinospora cordifolia (Guduchi) root extract on cardiotoxicity in streptozotocin induced diabetic rats,” Asian J. Biomed Pharmal Sci., vol. 5, pp. 12–19, 2015.
51. N. Kesarwani and L. Azmi, “Evaluation of cardioprotective effect of Tinospora cordifolia against isoprenaline induced myocardial infarction in rats,” Int. J. Current Microbiol. Appl. Sci., vol. 3, pp. 543–555, 2014.
52. G. Abiramasundari, K. R. Sumalatha, and M. Sreepriya, “Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro,” J. Ethnopharmacol., vol. 141, pp. 474–480, 2012.
53. G. Abiramasundari, C. M. Gowda, G. Pampapathi, S. Praveen, S. Shivamurugan, M. V. Kumar, A. Devi, and M. Sreepriya, “Ethnomedicine-based evaluation of osteoprotective properties of Tinospora cordifolia on in vitro and in vivo model systems,” Biomed. Pharmacother., vol. 87, pp. 342–354, 2017.
54. M. V. Kalikae, V. R. Thawani, U. K. Varadpande, S. D. Santakke, R. P. Singh, and R. K. Khiyani, “Immunomodulatory effect of T. Cordifolia extract in HIV positive patients,” Ind. J. Pharmacol., vol. 40, pp. 107–110, 2008.
55. S. Akhtar, “Use of T. Cordifolia in HIV infection,” Ind. J. Pharmacol., vol. 42, pp. 57–63, 2010.
56. G. Roja, A. S. Bhangale, A. R. Juvekar, S. Eapen, and S. F. D’Souza, “Enhanced production of the polysaccharide arabinogalactan using immobilized cultures of Tinospora cordifolia by elicitation and in situ adsorption,” Biotechnol. Prog., vol. 21, pp. 688–1691, 2005, doi: 10.1021/bp050188w.[2]
57. C. Nagaprashanthi, R. P. Khan, K. Gopichand, M. A. Aleemuddin, and G. R. Begum, “In-vitro antimicrobial activity of Tinospora cordifolia and its phytochemical screening,” Int. J. Pharm. Tech. Res., vol. 4, pp. 1004–1008, 2012.
58. U. M. Thatte, M. R. Kulkarni, and S. A. Dahanukar, “Immunotherapeutic modification of Escherichia coli peritonitis and bacteremia by Tinospora cordifolia,” J. Postgrad. Med., vol. 38, pp. 13–15, 1992.
59. M. A. Khan, “Tinospora cordifolia aqueous extract ameliorates the systemic infection of Aspergillus fumigatus in BALB/c mice,” Asian J. Pharmaceut. Clin. Res., vol. 12, pp. 525–528, 2019.
60. M. V. Kalikae, V. R. Thawani, U. K. Varadpande, S. D. Santakke, R. P. Singh, and R. K. Khiyani, “Immunomodulatory effect of T. Cordifolia extract in HIV positive patients,” Ind. J. Pharmacol., vol. 40, pp. 107–110, 2008.