Volume : 12, Issue : 01, January – 2025
Title:
A REVIEW ON HERBAL POTENTIAL FOR TREATMENT OF PEPTIC ULCER
Authors :
Pranjali S. Rathod, Kshitija Y. Khirodkar, Mr. Prashant Nalinde, Dr. Swati Deshmukh ,
Ankita Jadhav
Abstract :
Peptic ulcer disease (PUD) is a common gastrointestinal disorder marked by lesions in the stomach or duodenum lining, primarily caused by Helicobacter pylori infection, excessive use of nonsteroidal anti-inflammatory drugs (NSAIDs), and oxidative stress. Conventional therapies, including proton pump inhibitors and antibiotics, often present limitations such as side effects, recurrence, and antimicrobial resistance. This has driven interest in herbal medicines as potential alternatives or complementary therapies due to their natural origin, safety profile, and multifunctional properties. This review examines the therapeutic potential of medicinal plants and their bioactive constituents in the prevention and treatment of PUD. Key herbs such as *Glycyrrhiza glabra* (licorice), Zingiber officinale (ginger), Aloe vera, and Curcuma longa (turmeric) are highlighted for their anti-inflammatory, antioxidant, anti-H. pylori, and gastroprotective activities. Phytochemicals like flavonoids, tannins, alkaloids, and saponins are explored for their roles in promoting ulcer healing and enhancing mucosal defense. Although preclinical and some clinical studies show promising results, challenges such as variability in active compounds and limited standardization persist. This review emphasizes the need for rigorous clinical trials and standardized formulations to validate the safety and efficacy of herbal remedies, offering insights into their potential as sustainable solutions for peptic ulcer management.
Keywords : Peptic Ulcer, Helicobacter pylori, Gastrin, Herbs.
Cite This Article:
Please cite this article in press Pranjali S. Rathod et al., A Review On Herbal Potential For Treatment Of Peptic Ulcer.,Indo Am. J. P. Sci, 2025; 12 (01).
Number of Downloads : 10
References:
1. GI Consult: Perforated Peptic Ulcer; Retrieved (2007)-08-26.
2. Liu C, Crawford JM. Patologia–Bases patológicas das die-casting Robbins & Cortana, Kumar V, Abbas AK, Fausto N, Eds. Elsevier: Rio de Janeiro, Brazil, 2005; 7: 851 –857.
3. Bhowmik D, Chiranjib TK, Pankaj KS. Recent trends of treatment And medication peptic ulcerative disorder. Int J Pharm TechResearch. 2010;2(1):970-80.
4. Vyawahare N, Deshmukh V, Gadkari M, Kagathara V. Plants With antiulcer activity. Pharmacognosy Reviews. 2009;3(5):118.
5. Brooks FP. The pathophysiology of peptic ulcer disease. Digestive Diseases and Sciences. 1985 Nov;30(11):15S-29S.Doi: 10.1007/BF01309381.
6. Pawar R, Patil U, Gadekar R, Singour P, Chaurasiya P. A potential Of some medicinal plants as an antiulcer agent. Pharmacognosy Reviews Phcog Rev. 2010;4(8):136.Doi: 10.4103/0973-7847.70906; PMID: 22228953.
7. Nadkarni K, Nadkarni AK. Indian MateriaMedica, Popular Pr Cullen D.J., Hawkey G.M., Greenwood D.C., et al.; 1997; “Peptic ulcer bleeding in The elderly: relative roles of Helicobacter Pylori and non-steroidal anti-inflammatory Drugs”. Gut ; 41 (4): 459–62
8. “Asparagus racemosus information from NPGS/GRIN”. Germplasm Resources Information Network. USDA. August 6, 2002. Retrieved April 25, 2009.
9. Asparagus racemosus—Ethno pharmacological evaluation and Conservation needs. [Review] [77 refs] Bopana N. Saxena S.; 2007; Journal of Ethnopharmacology. 110(1):1-15.
10. Wagner, Hildebert; 1999; Immunomodulatory agents from plants.
11. Birkhäuser; 294. ISBN 9783764358488.
12. Hollander, D. (1994). Gastrointestinal complications of nonsteroidal anti-inflammatory drugs: Prophylactic and therapeutic strategies. American Journal of Medicine, 96(3), 274-281.
13. Winston D. &Mimes S.; 2007; “Adaptogens: Herbs for Strength, Stamina, And Stress Relief,” Healing Arts Press.
14. Singh S.S., Pandey S., Srivastava V.S., Gupta B., Patro A.C.; 2003; Ghoshchemistry And Medicinal Properties Of Tinospora Cordifolia (Guduchi) Indian Journal Of Pharmacology; 35: 83-91
15. Blamey M. & Grey-Wilson C.; 1989; Flora Of Britain and Northern Europe. ISBN 0-340-401702.
16. Holtmann, G., & Talley, N.J. (2015). Herbal medicines for the treatment of functional and inflammatory bowel disorders. Clinical Gastroenterology and Hepatology, 13(3), 422-432.
17. Heffern, Richard; Complete Book of Ginseng by Heffern.; 98.
18. Sun X. B., Matsumoto T., and Yamada H.; 1992;Anti-ulcer activity and mode of action Of the polysaccharide fraction from the Leaves of Panax ginseng. Planta Med ; 58(5):432-435.
19. Krishna KL, Paridhavi M, Patel JA. “Review on nutritional, medicinal and pharmacological properties of Papaya (Carica papaya Linn.).” Natural Product Radiance. 2008;7(4):364-373.papaya-oral/article.htm
20. Kuna, L., Jakab, J., Smolic, R., et al. Peptic ulcer disease: A brief review of conventional therapy and herbal treatment options. Journal of Clinical Medicine, 2019.
21. Serafim, C., Araruna, M.E., Hiruma-Lima, C.A., et al. A review of the role of flavonoids in peptic ulcer (2010–2020). Molecules, 2020.
22. Scartezzini P, Speroni E. “Review on some plants of Indian traditional medicine with antioxidant activity.” Journal of Ethnopharmacology. 2000;71(1–2):23–43.s/emblica_officinalis.pdf
23. Lewis, D.A., Hanson, P.J. Anti-ulcer drugs of plant origin. Progress in Medicinal Chemistry, 1991.
24. Dash, Vaidya Bhagwan. Herbal Treatment for Peptic Ulcer. Bjain Publishers.
25. Kuna, L., Jakab, J., Smolic, R., et al. (2019). Peptic ulcer disease: A brief review of conventional therapy and herbal treatment options. Journal of Clinical Medicine, 8(2), 179.
26. Serafim, C., Araruna, M.E., Hiruma-Lima, C.A., et al. (2020). A review of the role of flavonoids in peptic ulcer (2010–2020). Molecules, 25(22), 5431.
27. Phytochemistry, efficacy, and safety of medicinal plants used traditionally for the management of peptic ulcer diseases in Ethiopia: a systematic review
28. Boparai, V., Rajagopalan, J., & Triadafilopoulos, G. (2008). Guide to the use of proton pump inhibitors in adult patients. Drugs, 68(7), 925-947.