Volume : 12, Issue : 01, January – 2025

Title:

A DETAILED REVIEW ON FORMULATION & EVALUATION OF FAST DISSOLVING ORAL FILM

Authors :

Gaurav S. Avhale, Ashish D. Gadge, Rahul S. Mante, Adesh S. Wankhade, Dr. Aijaz A. Shaikh, Dr.K. R. Biyani

Abstract :

Drug delivery systems have evolved significantly, aiming to improve therapeutic efficacy, patient compliance, and bioavailability while minimizing the limitations associated with traditional oral and parenteral routes of administration. Among the various novel drug delivery systems, buccal drug delivery has gained considerable attention due to its ability to bypass first-pass metabolism, reduce gastrointestinal degradation, and enhance the bioavailability of certain drugs. The buccal mucosa, located in the oral cavity, serves as a promising site for drug absorption due to its rich vascularization, relatively thin epithelial layer, and proximity to systemic circulation.
The conventional oral route often suffers from drawbacks such as variable drug absorption, degradation by gastrointestinal enzymes, and first-pass metabolism, leading to reduced drug bioavailability and higher doses required to achieve therapeutic efficacy. Buccal drug delivery offers an attractive alternative by ensuring the drug is absorbed directly into the systemic circulation, thereby enhancing bioavailability and reducing the frequency of dosing. Among the various buccal drug delivery systems, macoadhesive systems, which utilize bioadhesive materials, have emerged as particularly promising. These macoadhesive systems prolong the residence time of the drug at the buccal mucosa, thereby facilitating sustained and controlled drug release.

Cite This Article:

Please cite this article in press Gaurav S. Avhale et al., Detailed Review On Formulation & Evaluation Of Fast Dissolving Oral Film.,Indo Am. J. P. Sci, 2025; 12 (01).,

Number of Downloads : 10

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